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oai:riuma.uma.es:10630/264042026-02-03T11:22:14Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Ávila-Gámiz, Fabiola author Pérez-Cano, Ana María author Pérez-Berlanga, José Manuel author Mullor-Vigo, Rosa author Zambrana-Infantes, Emma author Santín-Núñez, Luis Javier author Ladrón de Guevara-Miranda, David author 2023 Combining physical and cognitive training has been suggested to promote further benefits on brain and cognition, which could include synergistic improvement of hippocampal neuroplasticity. In this paper, we investigated whether treadmill exercise followed by a working memory training in the water maze increase adult hippocampal neurogenesis to a greater extent than either treatment alone. Our results revealed that ten days of scheduled running enhance cell proliferation/survival in the short-term as well as performance in the water maze. Moreover, exercised mice that received working memory training displayed more surviving dentate granule cells compared to those untreated or subjected to only one of the treatments. According to these findings, we suggest that combining physical and cognitive stimulation yield synergic effects on adult hippocampal neurogenesis by extending the pool of newly-born cells and subsequently favouring their survival. Future research could take advantage from this non-invasive, multimodal approach to achieve substantial and longer-lasting enhancement in adult hippocampal neurogenesis, which might be relevant for improving cognition in healthy or neurologically impaired conditions. F. Ávila-Gámiz, A.M. Pérez-Cano, J.M. Pérez-Berlanga, R.M. Mullor-Vigo, E.N. Zambrana-Infantes, L.J. Santín, D. Ladrón de Guevara-Miranda, Sequential treadmill exercise and cognitive training synergistically increase adult hippocampal neurogenesis in mice, Physiology & Behavior, Volume 266, 2023, 114184, ISSN 0031-9384, https://doi.org/10.1016/j.physbeh.2023.114184. https://hdl.handle.net/10630/26404 https://doi.org/10.1016/j.physbeh.2023.114184 Neurogénesis Hipocampo (cerebro) Sequential treadmill exercise and cognitive training synergistically increase adult hippocampal neurogenesis in mice