2026-05-28T14:55:06Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/272492026-02-03T12:01:14Zcom_10630_2254col_10630_37959
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
López-de-San-Sebastián, Javier
author
Rodríguez-Pérez, Luis Manuel
author
Anguita-Guardia, Alba
author
Jiménez-Lara, Antonio Jesús
author
Páez-González, Patricia
2023-07-14T10:21:13Z
2023-07-14T10:21:13Z
2023
https://hdl.handle.net/10630/27249
Germinal matrix hemorrhages and intraventricular hemorrhages (GMH/IVH) lead to posthemorrhagic hydrocephalus (PHH), a severe cause of morbidity and mortality in premature neonates. GMH/IVH disrupts the ependyma, which forms a physical and functional barrier between the brain parenchyma and the cerebrospinal fluid (CSF). CSF circulation and physiology is also affected by ependyma disruption. Thus, ependyma is a key target when designing PHH treatments. Despite this, hydrocephalus treatments are surgical and focused on alleviating ventricular pressure by draining CSF. No therapy is currently aimed to recover the ependyma. Nevertheless, bone marrow derived mesenchymal stem cells (MSCs) are known to be great agents when dealing with inflammation. Also, exosomes have proven to be promising tools when designing anti-inflammatory treatments. Therefore, gaining insight in the treating capabilities of MSCs exosomes in PHH can be valuable.
Results
Differential effects in edema progression and ependymal cells ciliogenesis are found when analyzing treatments with conditioned and non-conditioned exosomes in moderate PHH and severe PHH.
eng
Hidrocefalia - Tratamiento
Terapia celular - Ensayos
Testing exosomes as a treatment for posthemorrhagic hydrocephalus.
conference output
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URL
https://riuma.uma.es/bitstreams/64cc7267-0615-4977-8a3e-5c74383436f6/download
File
MD5
d7e6d6272c03745f70d4395cc94cb112
114139
application/pdf
SRHSB 2023.pdf