2026-06-02T07:25:09Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/274352026-02-03T11:32:59Zcom_10630_2254col_10630_37953

Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity. González Vidal, Alejandro Mercado-Sáenz, Silvia Burgos-Molina, Antonio Manuel Alamilla Presuel, Juan Carlos Alcaraz, Miguel Sendra-Portero, Francisco Ruiz-Gómez, Miguel José Saccharomyces cerevisiae - Efectos del estrés Saccharomyces cerevisiae - Efectos de la radiación Celulas - Metabolismo Estrés oxidativo Levaduras The repair of the damage produced to the genome and proteome by the action of ionizing radiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many of the metabolic pathways influence multiple processes. In this way, this work aims to study the relationship between resistance/response to ionizing radiation, cellular aging, and the response mechanisms to oxidative stress, free radicals, reactive oxygen species (ROS), and antioxidant activity in the yeast S. cerevisiae. Systems biology allows us to use tools that reveal the molecular mechanisms common to different cellular response phenomena. The results found indicate that homologous recombination, non-homologous end joining, and base excision repair pathways are the most important common processes necessary to maintain cellular homeostasis. The metabolic routes of longevity regulation are those that jointly contribute to the three phenomena studied. This study proposes eleven common biomarkers for response/resistance to ionizing radiation and aging (EXO1, MEC1, MRE11, RAD27, RAD50, RAD51, RAD52, RAD55, RAD9, SGS1, YKU70) and two biomarkers for response/resistance to radiation and oxidative stress, free radicals, ROS, and antioxidant activity (NTG1, OGG1). In addition, it is important to highlight that the HSP104 protein could be a good biomarker common to the three phenomena studied. 2023-09-05T09:56:07Z 2023-09-05T09:56:07Z 2023-09-05T09:56:07Z 2023-08-30 journal article González-Vidal, A.; Mercado-Sáenz, S.; Burgos-Molina, A.M.; Alamilla-Presuel, J.C.; Alcaraz, M.; Sendra-Portero, F.; Ruiz-Gómez, M.J. Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity. Antioxidants 2023, 12, 1690. https://doi.org/ 10.3390/antiox12091690 https://hdl.handle.net/10630/27435 10.3390/antiox12091690 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI