2026-05-31T10:15:00Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/278552026-02-03T11:29:15Zcom_10630_2254col_10630_37953

Association between exposure to air pollution and blood lipids in the general population of Spain. Valdés Hernández, Sergio Doulatram Gamgaram, Viyey Kishore Maldonado Araque, Cristina García-Escobar, Eva García Serrano, Sara Oualla-Bachiri, Wasima García- Vivanco, Marta Garrido, Juan Luis Gil, Victoria Martín-Llorente, Fernando Calle-Pascual, Alfonso Castaño, Luís Delgado, Elías Menéndez, Edelmiro Franch-Nadal, Josep Gaztambide, Sonia Girbés, Joan Chaves, F. Javier Galán-García, José Luis Aguilera-Venegas, Gabriel Vallvé, Joan Carles Amigó, Nuria Guardiola, Montse Ribalta, Josep Rojo-Martínez, Gemma Colesterol Lipoproteínas de alta densidad Lípidos sanguíneos Triglicéridos Aire - Contaminación Background and Aims: We aimed to assess the associations of exposure to air pollutants and standard and advanced lipoprotein measures, in a nationwide sample representative of the adult population of Spain.Methods: We included 4647 adults (>18 years), participants in the national, cross- sectional, population- based di@bet.es study, conducted in 2008– 2010. Standard lipid measurements were analysed on an Architect C8000 Analyzer (Abbott Laboratories SA). Lipoprotein analysis was made by an advanced 1H- NMR lipoprotein test (Liposcale®). Participants were assigned air pollution con-centrations for particulate matter <10 μm (PM10), <2.5 μm (PM2.5) and nitrogen dioxide (NO2), corresponding to the health examination year, obtained by mod-elling combined with measurements taken at air quality stations (CHIMERE chemistry- transport model).Results: In multivariate linear regression models, each IQR increase in PM10, PM2.5 and NO2 was associated with 3.3%, 3.3% and 3% lower levels of HDL- c and 1.3%, 1.4% and 1.1% lower HDL particle (HDL- p) concentrations (p< .001 for all associations). In multivariate logistic regression, there was a significant associa-tion between PM10, PM2.5 and NO2 concentrations and the odds of presenting low HDL- c (<40 mg/dL), low HDL- p (<p25) and higher LDL particle (LDL- p) concentrations (≥p75). In subgroup analyses there were stronger associations be-tween PM10 and NO2 and low HDL- p in men (p for interaction .008 and .034), and between NO2 and low HDL- p in individuals with obesity (p for interaction .015).Conclusions: Our study shows an association between the exposure to air pol-lutants and blood lipids in the general population of Spain, suggesting a link to atherosclerosis 2023-10-17T10:55:26Z 2023-10-17T10:55:26Z 2023-10-17T10:55:26Z 2023-09-23 journal article Valdés, S, Doulatram-Gamgaram, V, Maldonado-Araque, C, et al. Association between exposure to air pollution and blood lipids in the general population of Spain. Eur J Clin Invest. 2023; 00:e14101. doi:10.1111/eci.14101 https://hdl.handle.net/10630/27855 10.1111/eci.14101 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Wiley