2026-05-30T11:39:36Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/281192026-02-03T12:28:13Zcom_10630_2254col_10630_37959

Glycomimetic Ligands for C-type Lectin Recognition. Luna León, Rubén Reina Martín, José Juan Lectinas Ligandos Química orgánica C-type lectin receptors (CLRs) represent pivotal sensory mechanisms orchestrating the primary immune response via dendritic cells.1 The exploration of non-native ligands as molecular tools for the manipulation of CLRs has emerged as a highly interesting research area. In the case of DC-SIGN, one of the most extensively investigated CLRs, glycomimetics have been formulated as principal compounds with a demonstrated capacity to proficiently engage DC-SIGN (Figure 1 and 2). The principal problem encountered refers to the structural complexity and challenging synthetic processes associated with these glycomimetics. In this context, we introduce a novel class of glycomimetic ligands designed for DC-SIGN that exhibit a simpler structural composition and can be readily synthesized. These ligands hold significant promise for potential applications in the field of immune regulation therapeutic (Figure 3). 2023-11-23T07:48:02Z 2023-11-23T07:48:02Z 2023-11-23T07:48:02Z 2023 conference output https://hdl.handle.net/10630/28119 eng XIX Simposio de Jóvenes Investigadores Químicos de la RSEQ Murcia 13-11-2023/16-11-2023 open access