2026-05-28T13:05:04Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/286242026-02-03T11:18:11Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Varela-Moreno, Esperanza author Rivas-Ruiz, Francisco author Padilla Ruiz, María del Carmen author Alcaide-García, Julia author Zarcos-Pedrinaci, Irene author Téllez-Santana, Teresa author Fernández-de Larrea-Baz, Nerea author Baré, Marisa author Bilbao, Amaia author Sarasqueta, Cristina author Morales-Suárez-Varela, María Manuela author Aguirre, Urko author Quintana, José María author Redondo-Bautista, Maximino author 2022-08-21 Objective The prevalence of depressive symptoms immediately after the diagnosis of colorectal cancer (CRC) is high and has important implications both psychologically and on the course of the disease. The aim of this study is to analyse the association between depressive symptoms and CRC survival at 5 years after diagnosis. Methods This multicentre, prospective, observational cohort study was conducted on a sample of 2602 patients with CRC who completed the Hospital Anxiety and Depression Scale (HADS-D) at 5 years of follow-up. Survival was analysed using the Kaplan–Meier method and Cox regression models. Results According to our analysis, the prevalence of depressive symptoms after a CRC diagnosis was 23.8%. The Cox regression analysis identified depression as an independent risk factor for survival (HR = 1.47; 95% CI: 1.21–1.8), a finding which persisted after adjusting for sex (female: HR = 0.63; 95% CI: 0.51–0.76), age (>70 years: HR = 3.78; 95% CI: 1.94–7.36), need for help (yes: HR = 1.43; 95% CI: 1.17–1.74), provision of social assistance (yes: HR = 1.46; 95% CI: 1.16–1.82), tumour size (T3–T4: HR = 1.56; 95% CI: 1.22–1.99), nodule staging (N1–N2: HR = 2.46; 95% CI: 2.04–2.96), and diagnosis during a screening test (yes: HR = 0.71; 95% CI: 0.55–0.91). Conclusions There is a high prevalence of depressive symptoms in patients diagnosed with CRC. These symptoms were negatively associated with the survival rate independently of other clinical variables. Therefore, patients diagnosed with CRC should be screened for depressive symptoms to ensure appropriate treatment can be provided. Varela‐MorenoE,Rivas‐RuizF,Padilla‐RuizM,etal.Influenceofdepressiononsurvivalofcolorectalcancerpatientsdrawnfromalargeprospectivecohort.Psychooncology.2022;31(10):1762‐1773.https://doi.org/10.1002/pon.6018 https://hdl.handle.net/10630/28624 10.1002/pon.6018 Oncología - Aspectos psicológicos Influence of depression on survival of colorectal cancer patients drawn from a large prospective cohort