2026-06-05T12:24:50Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/289152026-02-03T11:35:13Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Mayorga Mayorga, Cristobalina
author
Ariza, Adriana
author
Muñoz-Cano, Rosa
author
Sabato, Vito
author
Doña, Inmaculada
author
Torres-Jaén, María Josefa
2024-01-19T09:51:41Z
2024-01-19T09:51:41Z
2023-11-10
Mayorga C, Ariza A, Muñoz-Cano R, Sabato V, Doña I, Torres MJ. Biomarkers of immediate drug hypersensitivity. Allergy. 2023;00:1-12. doi:10.1111/ all.15933
https://hdl.handle.net/10630/28915
https://doi.org/10.1111/all.15933
Immediate drug hypersensitivity reactions (IDHRs) are a burden for patients and the health systems. This problem increases when taking into account that only a small proportion of patients initially labelled as allergic are finally confirmed after an allergological workup. The diverse nature of drugs involved will imply different interactions with the immunological system. Therefore, IDHRs can be produced by a wide array of mechanisms mediated by the drug interaction with specific antibodies or directly on effector target cells. These heterogeneous mechanisms imply an enhanced complexity for an accurate diagnosis and the identification of the phenotype and endotype at early stages of the reaction is of vital importance. Currently, several endophenotypic categories (type I IgE/non-IgE, cytokine release, Mast-related G-protein coupled receptor X2 (MRGPRX2) or Cyclooxygenase-1 (COX-1) inhibition and their associated biomarkers have been proposed. A precise knowledge of endotypes will permit to discriminate patients within the same phenotype, which is crucial in order to personalise diagnosis, future treatment and prevention to improve the patient's quality of life.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Biomedicina - Investigación
Biomarkers of immediate drug hypersensitivity
journal article
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Allergy - 2023 - Mayorga - Biomarkers of immediate drug hypersensitivity.pdf