2026-06-05T12:29:03Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/290862026-02-03T11:16:33Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Sánchez-Moreno, Paola
author
Ortega-Vinuesa, Juan Luis
author
Peula-García, José Manuel
author
Marchal, Juan Antonio
author
Boulaiz, Houria
2024-01-24T07:48:04Z
2024-01-24T07:48:04Z
2018-02
Sanchez-Moreno P, Ortega-Vinuesa JL, Peula-Garcia JM, Marchal JA, Boulaiz H. Smart Drug-Delivery Systems for Cancer Nanotherapy. Curr Drug Targets. 2018 Feb 19;19(4):339-359. doi: 10.2174/1389450117666160527142544. PMID: 27231107.
https://hdl.handle.net/10630/29086
10.2174/1389450117666160527142544
Despite all the advances achieved in the field of tumor-biology research, in most cases conventional therapies including chemotherapy are still the leading choices. The main disadvantage of these treatments, in addition to the low solubility of many antitumor drugs, is their lack of specificity, which leads to the occurrence of severe side effects due to nonspecific drug uptake by healthy cells. Progress in nanotechnology and its application in medicine have provided new opportunities and different smart systems. Such systems can improve the intracellular delivery of the drugs due to their multifunctionality and targeting potential. The purpose of this manuscript is to review and analyze the recent progress made in cancer nanotherapy. First, we provide a global overview of cancer and different smart nanoparticles currently used in oncology. Then, we analyze in detail the development of drug-delivery strategies in cancer therapy, focusing mainly on the intravenously administered smart nanoparticles with protein corona to avoid immune-system clearance. Finally, we discuss the challenges, clinical trials, marketed nanomedicines and future directions of the nanotherapy applied to cancer treatment.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Cáncer - Tratamiento
Smart drug-delivery systems for cancer nanotherapy
journal article
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URL
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File
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4823317823d9fbea20b801d5d6828579
680103
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Preprint Boulaiz-MS_Peula.pdf