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oai:riuma.uma.es:10630/294442026-02-03T11:08:26Zcom_10630_2254col_10630_37953

Barbancho-Fernández, Miguel Ángel Berthier-Torres, Marcelo Luis Navas-Sánchez, Patricia Dávila-Arias, María Guadalupe Green-Heredia, Cristina García-Alberca, J.M. Ruiz-Cruces, Rafael López-González, Manuel Víctor Dawid-Milner, Marc Stefan Pulvermüller, Friedemann Lara-Muñoz, José Pablo 2024-01-31T08:05:12Z 2024-01-31T08:05:12Z 2015 Miguel A. Barbancho, Marcelo L. Berthier, Patricia Navas-Sánchez, Guadalupe Dávila, Cristina Green-Heredia, José M. García-Alberca, Rafael Ruiz-Cruces, Manuel V. López-González, Marc S. Dawid-Milner, Friedemann Pulvermüller, J. Pablo Lara, Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study, Brain and Language, Volumes 145–146, 2015, Pages 1-10, ISSN 0093-934X, https://doi.org/10.1016/j.bandl.2015.04.003. https://hdl.handle.net/10630/29444 doi: 10.1016/j.bandl.2015.04.003 Changes in ERP (P100 and N400) and root mean square (RMS) were obtained during a silent reading task in 28 patients with chronic post-stroke aphasia in a randomized, double-blind, placebo-controlled trial of both memantine and constraint-induced aphasia therapy (CIAT). Participants received memantine/placebo alone (weeks 0–16), followed by drug treatment combined with CIAT (weeks 16–18), and then memantine/placebo alone (weeks 18–20). ERP/RMS values (week 16) decreased more in the memantine group than in the placebo group. During CIAT application (weeks 16–18), improvements in aphasia severity and ERP/RMS values were amplified by memantine and changes remained stable thereafter (weeks 18–20). Changes in ERP/RMS occurred in left and right hemispheres and correlated with gains in language performance. No changes in ERP/RMS were found in a healthy group in two separated evaluations. Our results show that aphasia recovery induced by both memantine alone and in combination with CIAT is indexed by bilateral cortical potentials. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Afasia - Tratamiento Cerebro - Hemorragia - Complicaciones y secuelas - Tratamiento Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study journal article