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oai:riuma.uma.es:10630/294482026-02-03T11:36:32Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Lara-Muñoz, José Pablo author Dawid-Milner, Marc Stefan author López-González, Manuel Víctor author Montes, Carmen author Spyer, KM author González-Barón, Salvador author 2002 In order to study the importance of two pontine regions modulating laryngeal resistance, electrical current or microinjections of glutamate (10–30 nl, 1–3 nmol) were made into the pontine parabrachial complex and the A5 region in spontaneously breathing anaesthetized rats. Two distinct patterns of laryngeal and respiratory responses were elicited. An increase of subglottal pressure was accompanied with an expiratory facilitatory response consisted of a decrease in both respiratory rate and phrenic nerve activity. A decrease of subglottal pressure was accompanied with an inspiratory facilitatory response consisted of an increase in both respiratory rate and phrenic nerve activity. The modification of laryngeal calibre occurred during both respiratory phases in most cases. The concomitant cardiovascular changes of these responses were also analyzed. Controls using guanethidine to block autonomic responses which might interact with respiratory control were also made. Histological analysis of stimulation sites showed a topographical organization of these responses: laryngeal constriction was evoked from Kölliker–Fuse, medial parabrachial nuclei and A5 region, whilst the laryngeal dilation was evoked from the lateral parabrachial nucleus. J.P Lara, M.S Dawid-Milner, M.V López, C Montes, K.M Spyer, S González-Barón, Laryngeal effects of stimulation of rostral and ventral pons in the anaesthetized rat, Brain Research, Volume 934, Issue 2, 2002, Pages 97-106, ISSN 0006-8993, https://doi.org/10.1016/S0006-8993(02)02364-8. https://hdl.handle.net/10630/29448 doi: 10.1016/s0006-8993(02)02364-8 Respiración - Regulación - Modelos animales Laringe - Modelos animales Experimentación animal Laryngeal effects of stimulation of rostral and ventral pons in the anaesthetized rat