2026-05-31T06:22:57Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/295542026-02-03T10:49:36Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Arrabal-García, Pilar María
author
Visser, Rick
author
Santos-Ruiz, Leonor
author
Becerra-Ratia, José
author
Cifuentes-Rueda, Manuel
2024-02-01T07:40:09Z
2024-02-01T07:40:09Z
2013
https://hdl.handle.net/10630/29554
10.4067/S0716-97602013000400013
Among the osteogenic growth factors used for bone tissue engineering, bone morphogenetic proteins (BMPs) are the most extensively studied for use in orthopaedic surgery. BMP-2 and BMP-7 have been widely investigated for developing therapeutic strategies and are the only two approved for use in several clinical applications. Due to the chemical and biological characteristics of these molecules, their authorised uses are always in combination with a carrier based on collagen type I. Although the use of these growth factors is considered safe in the short term, the very high doses needed to obtain significant osteoinduction make these treatments expensive and their long-term safety uncertain, since they are highly pleiotropic and have the capacity to induce ectopic ossification in the surrounding tissues. Therefore it is necessary to improve the currently used BMP-collagen system in terms of efficiency, biosecurity and costs. There are several strategies to increase the clinical effectiveness of these treatments. In this review we summarize the most promising results and our related work focused on this field through two different approaches: i) the development of recombinant BMPs with additional features, and ii) complementing these systems with other growth factors or molecules to enhance or accelerate osteogenesis.
eng
Huesos - Crecimiento
Osteogenic molecules for clinical applications: Improving the BMP-collagen system
journal article
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URL
https://riuma.uma.es/bitstreams/07533213-8fba-47b3-aa94-93562d24267b/download
File
MD5
a9ae603a58b974f87ffab018383c3604
336127
application/pdf
Arrabal BR_13.pdf