2026-06-02T12:28:02Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/295952026-02-03T11:36:18Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Contreras-Cáceres, Rafael
author
Cabeza, Laura
author
Perazzoli, Gloria
author
Díaz-Morilla, Amelia
author
López-Romero, Juan Manuel
author
Melguizo, Consolación
author
Prados, Jose
2024-02-01T11:21:20Z
2024-02-01T11:21:20Z
2019-04
Contreras-Cáceres R, Cabeza L, Perazzoli G, Díaz A, López-Romero JM, Melguizo C, Prados J. Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy. Nanomaterials (Basel). 2019 Apr 24;9(4):656. doi: 10.3390/nano9040656.
https://hdl.handle.net/10630/29595
10.3390/nano9040656
Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the encapsulation of antitumor drugs for controlled drug delivery applications, scaffolds structures for tissue engineering and regenerative medicine, as well as magnetic or plasmonic hyperthermia to be applied in the reduction of cancer tumors. This makes NFs useful as therapeutic implantable patches or mats to be implemented in numerous biomedical researching fields. In this context, several biocompatible polymers with excellent biocompatibility and biodegradability including poly lactic-co-glycolic acid (PLGA), poly butylcyanoacrylate (PBCA), poly ethylenglycol (PEG), poly (ε-caprolactone) (PCL) or poly lactic acid (PLA) have been widely used for the synthesis of NFs using the electrospun technique. Indeed, other types of polymers with stimuli-responsive capabilities has have recently reported for the fabrication of polymeric NFs scaffolds with relevant biomedical applications. Importantly, colloidal nanoparticles used as nanocarriers and non-biodegradable structures have been also incorporated by electrospinning into polymeric NFs for drug delivery applications and cancer treatments. In this review, we focus on the incorporation of drugs into polymeric NFs for drug delivery and cancer treatment applications. However, the principal novelty compared with previously reported publications is that we also focus on recent investigations concerning new strategies that increase drug delivery and cancer treatments efficiencies, such as the incorporation of colloidal nanoparticles into polymeric NFs, the possibility to fabricate NFs with the capability to respond to external environments, and finally, the synthesis of hybrid polymeric NFs containing carbon nanotubes, magnetic and gold nanoparticles, with magnetic and plasmonic hyperthermia applicability.
eng
Cáncer - Tratamiento
Medicamentos - Sistemas de administración
Medicamentos poliméricos - Sistemas de administración
Nanomedicina
Electrospun nanofibers: recent applications in drug delivery and cancer therapy
journal article
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https://riuma.uma.es/bitstreams/55073e7b-dce3-4b0c-82a0-847c0fef07b3/download
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b708e74739f17ee392ef72c576212e58
3531931
application/pdf
nanomaterials-09-00656.pdf