2026-05-30T08:38:10Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/296512026-02-03T10:53:57Zcom_10630_2254col_10630_37953

Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2 Merchante-Berg, Catharina Brumós, Javier Yun, Jeonga Hu, Qiwen Spencer, Kristina R Enríquez, Paul Binder, Brad M. Heber, Steffen Stepanova, Anna Alonso, José M. Etileno Hormonas vegetales The central role of translation in modulating gene activity has long been recognized, yet the systematic exploration of quantitative changes in translation at a genome-wide scale in response to a specific stimulus has only recently become technically feasible. Using the well-characterized signaling pathway of the phytohormone ethylene and plant-optimized genome-wide ribosome footprinting, we have uncovered a molecular mechanism linking this hormone's perception to the activation of a gene-specific translational control mechanism. Characterization of one of the targets of this translation regulatory machinery, the ethylene signaling component EBF2, indicates that the signaling molecule EIN2 and the nonsense-mediated decay proteins UPFs play a central role in this ethylene-induced translational response. Furthermore, the 3'UTR of EBF2 is sufficient to confer translational regulation and required for the proper activation of ethylene responses. These findings represent a mechanistic paradigm of gene-specific regulation of translation in response to a key growth regulator. 2024-02-01T13:44:59Z 2024-02-01T13:44:59Z 2015-10-22 journal article Merchante C, Brumos J, Yun J, Hu Q, Spencer KR, Enríquez P, Binder BM, Heber S, Stepanova AN, Alonso JM. Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2. Cell. 2015 Oct 22;163(3):684-97. doi: 10.1016/j.cell.2015.09.036. Epub 2015 Oct 22. PMID: 26496608. https://hdl.handle.net/10630/29651 10.1016/j.cell.2015.09.036 spa open access ELSEVIER