2026-05-28T03:10:48Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/296692026-02-03T10:50:19Zcom_10630_2254col_10630_37953

Izquierdo-Barba, Isabel Santos-Ruiz, Leonor Becerra-Ratia, José Feito, M.J. Fernández-Villa, D. Serrano, M.C. Díaz-Güemes, I. Fernández-Tomé, B. Enciso, S. Sánchez-Margallo, F.M. Monopoli, Donato Alfonso, H. Portolés, María Teresa Arcos, Daniel Vallet-Regí, M. 2024-02-02T08:05:23Z 2024-02-02T08:05:23Z 2019-01-01 https://hdl.handle.net/10630/29669 10.1016/j.actbio.2018.11.017 The osteogenic and angiogenic responses to metal macroporous scaffolds coated with silicon substituted hydroxyapatite (SiHA) and decorated with vascular endothelial growth factor (VEGF) have been evaluated in vitro and in vivo. Ti6Al4V-ELI scaffolds were prepared by electron beam melting and subsequently coated with Ca-10(PO4)(5.6)(SRO4)(0.4)(OH)(1.6) following a dip coating method. In vitro studies demonstrated that SiHA stimulates the proliferation of MC3T3-E1 pre-osteoblastic cells, whereas the adsorption of VEGF stimulates the proliferation of EC2 mature endothelial cells. In vivo studies were carried out in an osteoporotic sheep model, evidencing that only the simultaneous presence of both components led to a significant increase of new tissue formation in osteoporotic bone. eng open access Huesos - Crecimiento Synergistic effect of Si-hydroxyapatite coating and VEGF adsorption on Ti6Al4V-ELI scaffolds for bone regeneration in an osteoporotic bone environment journal article