2026-05-28T19:55:56Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/298362026-02-03T11:09:58Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Solé, Ricard V. author Valverde, Sergi author Rodríguez-Caso, Carlos Francisco author Sardanyés, Josep author 2014-04 Genomic instability is a hallmark of cancer. Cancer cells that exhibit abnormal chromosomes are characteristic of most advanced tumours, despite the potential threat represented by accumulated genetic damage. Carcinogenesis involves a loss of key components of the genetic and signalling molecular networks; hence some authors have suggested that this is part of a trend of cancer cells to behave as simple, minimal replicators. In this study, we explore this conjecture and suggest that, in the case of cancer, genomic instability has an upper limit that is associated with a minimal cancer cell network. Such a network would include (for a given microenvironment) the basic molecular components that allow cells to replicate and respond to selective pressures. However, it would also exhibit internal fragilities that could be exploited by appropriate therapies targeting the DNA repair machinery. The implications of this hypothesis are discussed. Solé, Ricard V., Sergi Valverde, Carlos Rodriguez‐Caso, and Josep Sardanyés. "Can a minimal replicating construct be identified as the embodiment of cancer?." Bioessays 36, no. 5 (2014): 503-512. doi.org/10.1002/bies.201300098 https://hdl.handle.net/10630/29836 https://doi.org/10.1002/bies.201300098 Carcinogénesis - Aspectos moleculares Can a minimal replicating construct be identified as the embodiment of cancer?