2026-05-30T22:54:45Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/299092026-02-03T11:31:13Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Claros-Gil, Silvia author Cabrera, Pablo author Valverde, María author Romero-Zerbo, Silvana Yanina author López-González, Manuel Víctor author Shumilov, Kirill author Rivera-Ramírez, Alicia author Pavía-Molina, José author Martín-Montañez, Elisa author García-Fernández, María Inmaculada author 2021-12-24 Stress seems to contribute to Parkinson’s disease (PD) neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors in this pathophysiology are oxidative stress and mitochondrial dysfunction and neuronal glucocorticoid-induced toxicity. The insulin-like growth factor II (IGF-II), a pleiotropic hormone, has shown antioxidant and neuroprotective effects in some neurodegenerative disorders. Our aim was to examine the protective effect of IGF-II on a dopaminergic cellular combined model of PD and mild to moderate stress measuring oxidative stress parameters, mitochondrial and neuronal markers, and signalling pathways. IGF-II counteracts the mitochondrial-oxidative damage produced by the toxic synergistic effect of corticosterone and 1-methyl-4-phenylpyridinium, protecting dopaminergic neurons from death and neurodegeneration. IGF-II promotes PKC activation and nuclear factor (erythroid-derived 2)-like 2 antioxidant response in a glucocorticoid receptor-dependent pathway, preventing oxidative cell damage and maintaining mitochondrial function. Thus, IGF-II is a potential therapeutic tool for treatment and prevention of disease progression in PD patients suffering mild to moderate emotional stress. Claros, S.; Cabrera, P.; Valverde, N.; Romero-Zerbo, S.Y.; López-González, M.V.; Shumilov, K.; Rivera, A.; Pavia, J.; Martín-Montañez, E.; Garcia-Fernandez, M. Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons. Antioxidants 2022, 11, 41. https://doi.org/10.3390/antiox11010041 https://hdl.handle.net/10630/29909 10.3390/antiox11010041 Parkinson, Enfermedad de Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons