2026-05-28T00:28:39Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/299092026-02-03T11:31:13Zcom_10630_2254col_10630_37953

Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons Claros-Gil, Silvia Cabrera, Pablo Valverde, María Romero-Zerbo, Silvana Yanina López-González, Manuel Víctor Shumilov, Kirill Rivera-Ramírez, Alicia Pavía-Molina, José Martín-Montañez, Elisa García-Fernández, María Inmaculada Parkinson, Enfermedad de Stress seems to contribute to Parkinson’s disease (PD) neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors in this pathophysiology are oxidative stress and mitochondrial dysfunction and neuronal glucocorticoid-induced toxicity. The insulin-like growth factor II (IGF-II), a pleiotropic hormone, has shown antioxidant and neuroprotective effects in some neurodegenerative disorders. Our aim was to examine the protective effect of IGF-II on a dopaminergic cellular combined model of PD and mild to moderate stress measuring oxidative stress parameters, mitochondrial and neuronal markers, and signalling pathways. IGF-II counteracts the mitochondrial-oxidative damage produced by the toxic synergistic effect of corticosterone and 1-methyl-4-phenylpyridinium, protecting dopaminergic neurons from death and neurodegeneration. IGF-II promotes PKC activation and nuclear factor (erythroid-derived 2)-like 2 antioxidant response in a glucocorticoid receptor-dependent pathway, preventing oxidative cell damage and maintaining mitochondrial function. Thus, IGF-II is a potential therapeutic tool for treatment and prevention of disease progression in PD patients suffering mild to moderate emotional stress. 2024-02-06T12:01:39Z 2024-02-06T12:01:39Z 2024-02-05 2021-12-24 journal article Claros, S.; Cabrera, P.; Valverde, N.; Romero-Zerbo, S.Y.; López-González, M.V.; Shumilov, K.; Rivera, A.; Pavia, J.; Martín-Montañez, E.; Garcia-Fernandez, M. Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons. Antioxidants 2022, 11, 41. https://doi.org/10.3390/antiox11010041 https://hdl.handle.net/10630/29909 10.3390/antiox11010041 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI