2026-06-01T08:31:06Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/302412026-02-03T11:03:37Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Martinez-Ortega, J.
author
Funes-Godoy, Silvia
author
Diaz-Atienza, Francisco
author
Gutiérrez-Rojas, Luis
author
Pérez-Costillas, Lucía María
author
Gurpegui, Manuel
2024-02-09T09:18:54Z
2024-02-09T09:18:54Z
2013
Martínez-Ortega, J. M., Funes-Godoy, S., Díaz-Atienza, F., Gutiérrez-Rojas, L., Pérez-Costillas, L., & Gurpegui, M. (2013). Weight gain and increase of body mass index among children and adolescents treated with antipsychotics: a critical review. European child & adolescent psychiatry, 22(8), 457–479.
1018-8827
https://hdl.handle.net/10630/30241
10.1007/s00787-013-0399-5
We performed an updated review of the available literature on weight gain and increase of body mass index (BMI) among children and adolescents treated with antipsychotic medications. A PubMed search was conducted specifying the following MeSH terms: (antipsychotic agents) hedged with (weight gain) or (body mass index). We selected 127 reports, including 71 intervention trials, 42 observational studies and 14 literature reviews. Second-generation antipsychotics (SGAs), in comparison with first-generation antipsychotics, are associated with a greater risk for antipsychotic-induced weight gain although this oversimplification should be clarified by distinguishing across different antipsychotic drugs. Among SGAs, olanzapine appears to cause the most significant weight gain, while ziprasidone seems to cause the least. Antipsychotic-induced BMI increase appears to remain regardless of the specific psychotropic co-treatment. Children and adolescents seem to be at a greater risk than adults for antipsychotic-induced weight gain; and the younger the child, the higher the risk. Genetic or environmental factors related to antipsychotic-induced weight gain among children and adolescents are mostly unknown, although certain genetic factors related to serotonin receptors or hormones such as leptin, adiponectin or melanocortin may be involved. Strategies to reduce this antipsychotic side effect include switching to another antipsychotic drug, lowering the dosage or initiating treatment with metformin or topiramate, as well as non-pharmacological interventions. Future research should avoid some methodological limitations such as not accounting for age- and sex-adjusted BMI (zBMI), small sample size, short period of treatment, great heterogeneity of diagnoses and confounding by indication.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Neurolépticos
Peso
Weight gain and increase of body mass index among children and adolescents treated with antipsychotics: a critical review
journal article
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https://riuma.uma.es/bitstreams/316c1235-0c07-4c6e-9953-fddae8e38b5c/download
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22815380bfaf582782a10deb3be3aeae
1065335
application/pdf
weight gain1.pdf