2026-05-28T08:02:44Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/302952026-02-03T10:52:22Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Maravilla-Herrera, Paulina author Merino, Maria author Alfonso Zamora, Santiago author Balea Filgueiras, Jesús author Carrascosa Carrillo, José Manuel author Delgado Sánchez, Olga author Dolz Sinisterra, Francisco author García-Ruiz, Antonio J. author Herranz Pinto, Pedro author Manfredi, Antonio author Martínez Olmos, José author Morales de los Ríos Luna, Paloma author Puig, Lluís author Ros, Sandra author Hidalgo-Vega, Álvaro author 2023 Therapeutic advances have made PASI 90 or PASI 100 responses possible in most patients treated with some biologics. A greater response may generate social value beyond clinical outcomes that would benefit both patients and society. Methods: A 1-year economic model was applied to estimate the impact of having a PASI 75, PASI 90, or PASI 100 response in four areas of analysis (quality of life, activities of daily living, work productivity, and out-of-pocket expenditures) and the social value of having a PASI 90 or PASI 100 response in comparison with a PASI 75 response. A mixed-methods approach based on the scientific literature, a focus group with patient, and an advisory committee with psoriasis stakeholders was used. The model included three diferent scenarios: having a PASI 90 vs a PASI 75 response; a PASI 100 vs a PASI 90 response; and a PASI 100 vs a PASI 75 response. A sensitivity analysis was included. Results: The annual economic impact per patient with moderate-to-severe plaque psoriasis having a PASI 75 response was estimated at Ł 6,139, mainly related to labour productivity losses and quality of life reductions. Having a PASI 90 or a PASI 100 response would reduce this impact to e3,956 or e1,353, respectively. Accordingly, the social value of having a PASI 90 instead of a PASI 75 response was estimated at e2,183, and e4,786 with a PASI 100 response. Discussion: A PASI 90 or PASI 100 response would have a lower economic impact and a greater social value than a PASI 75 response for patients with moderate-to-severe plaque psoriasis. Maravilla-Herrera P, Merino M, Alfonso Zamora S, Balea Filgueiras J, Carrascosa Carrillo JM, Delgado Sánchez O, Dolz Sinisterra F, García-Ruiz A, Herranz Pinto P, Manfredi A, Martínez Olmos J, Morales de los Ríos Luna P, Puig L, Ros S and Hidalgo-Vega Á (2023) The social value of a PASI 90 or PASI 100 response in patients with moderate-to-severe plaque psoriasis in Spain. Front. Public Health 11. doi:10.3389/fpubh.2023.1000776 https://hdl.handle.net/10630/30295 10.3389/fpubh.2023.1000776 Psoriasis - Tratamiento Psoriasis - Aspectos sociales The social value of a PASI 90 or PASI 100 response in patients with moderate-to-severe plaque psoriasis in Spain