2026-06-05T17:22:46Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/302952026-02-03T10:52:22Zcom_10630_2254col_10630_37953

The social value of a PASI 90 or PASI 100 response in patients with moderate-to-severe plaque psoriasis in Spain Maravilla-Herrera, Paulina Merino, Maria Alfonso Zamora, Santiago Balea Filgueiras, Jesús Carrascosa Carrillo, José Manuel Delgado Sánchez, Olga Dolz Sinisterra, Francisco García-Ruiz, Antonio J. Herranz Pinto, Pedro Manfredi, Antonio Martínez Olmos, José Morales de los Ríos Luna, Paloma Puig, Lluís Ros, Sandra Hidalgo-Vega, Álvaro Psoriasis - Tratamiento Psoriasis - Aspectos sociales Social return Socioeconomic impact Psoriasis Quality of life Out-of-pocket (OOP) expenses Activities of daily living Therapeutic advances have made PASI 90 or PASI 100 responses possible in most patients treated with some biologics. A greater response may generate social value beyond clinical outcomes that would benefit both patients and society. Methods: A 1-year economic model was applied to estimate the impact of having a PASI 75, PASI 90, or PASI 100 response in four areas of analysis (quality of life, activities of daily living, work productivity, and out-of-pocket expenditures) and the social value of having a PASI 90 or PASI 100 response in comparison with a PASI 75 response. A mixed-methods approach based on the scientific literature, a focus group with patient, and an advisory committee with psoriasis stakeholders was used. The model included three diferent scenarios: having a PASI 90 vs a PASI 75 response; a PASI 100 vs a PASI 90 response; and a PASI 100 vs a PASI 75 response. A sensitivity analysis was included. Results: The annual economic impact per patient with moderate-to-severe plaque psoriasis having a PASI 75 response was estimated at Ł 6,139, mainly related to labour productivity losses and quality of life reductions. Having a PASI 90 or a PASI 100 response would reduce this impact to e3,956 or e1,353, respectively. Accordingly, the social value of having a PASI 90 instead of a PASI 75 response was estimated at e2,183, and e4,786 with a PASI 100 response. Discussion: A PASI 90 or PASI 100 response would have a lower economic impact and a greater social value than a PASI 75 response for patients with moderate-to-severe plaque psoriasis. 2024-02-09T12:15:02Z 2024-02-09T12:15:02Z 2023 journal article VoR Maravilla-Herrera P, Merino M, Alfonso Zamora S, Balea Filgueiras J, Carrascosa Carrillo JM, Delgado Sánchez O, Dolz Sinisterra F, García-Ruiz A, Herranz Pinto P, Manfredi A, Martínez Olmos J, Morales de los Ríos Luna P, Puig L, Ros S and Hidalgo-Vega Á (2023) The social value of a PASI 90 or PASI 100 response in patients with moderate-to-severe plaque psoriasis in Spain. Front. Public Health 11. doi:10.3389/fpubh.2023.1000776 https://hdl.handle.net/10630/30295 10.3389/fpubh.2023.1000776 eng Attribution 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ open access application/pdf Hai Fang, Peking University, China