2026-06-02T01:20:58Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/305202026-02-03T11:34:51Zcom_10630_2254col_10630_37953

Dendritic scaffold onto titanium implants. A versatile strategy increasing biocompatibility. Molina, Noemí González, Ana Monopoli, Donato Mentado, Belinda Becerra-Ratia, José Santos-Ruiz, Leonor Vida-Pol, Yolanda Pérez-Inestrosa, Ezequiel Implantes artificiales Células dendríticas Implantes dentales Titanio Huesos Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with "organic" ceramics, such as hydroxyapatite. A novel approach is hereby presented, immobilizing covalently dendrimeric structures onto titanium implants. Amide-based amino terminal dendrons were synthetized and coupled to titanium surfaces in a versatile and controlled way. The dendritic moieties provide an excellent scaffold for the covalent immobilization of bioactive molecules, such as extracellular matrix (ECM) protein components or antibiotics. Herein, tripeptide arginine-glycine-aspartic acid (RGD) motifs were used to decorate the dendritic scaffolds and their influence on cell adhesion and proliferation processes was evaluated. 2024-02-19T12:40:08Z 2024-02-19T12:40:08Z 2024-02-19T12:40:08Z 2020-04-01 journal article Molina, N.; González, A.; Monopoli, D.; Mentado, B.; Becerra, J.; Santos-Ruiz, L.; Vida, Y.; Perez-Inestrosa, E. Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility. Polymers 2020, 12, 770. 2073-4360 https://hdl.handle.net/10630/30520 10.3390/polym12040770 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI