2026-06-07T05:25:39Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/305292026-02-03T11:15:38Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Kazantseva, Liliya
author
Becerra-Ratia, José
author
Santos-Ruiz, Leonor
2024-02-20T07:13:42Z
2024-02-20T07:13:42Z
2022-08-06
1420-3049
https://hdl.handle.net/10630/30529
10.3390/molecules27155008
Osteosarcoma is one of the most common types of bone cancers among paediatric patients. Despite the advances made in surgery, chemo-, and radiotherapy, the mortality rate of metastatic osteosarcoma remains unchangeably high. The standard drug combination used to treat this bone cancer has remained the same for the last 20 years, and it produces many dangerous side effects. Through history, from ancient to modern times, nature has been a remarkable source of chemical diversity, used to alleviate human disease. The application of modern scientific technology to the study of natural products has identified many specific molecules with anti-cancer properties. This review describes the latest discovered anti-cancer compounds extracted from traditional medicinal plants, with a focus on osteosarcoma research, and on their cellular and molecular mechanisms of action. The presented compounds have proven to kill osteosarcoma cells by interfering with different pathways: apoptosis induction, stimulation of autophagy, generation of reactive oxygen species, etc. This wide variety of cellular targets confer natural products the potential to be used as chemotherapeutic drugs, and also the ability to act as sensitizers in drug combination treatments. The major hindrance for these molecules is low bioavailability. A problem that may be solved by chemical modification or nano-encapsulation.
eng
Atribución 4.0 Internacional
Huesos - Cáncer
Fitoterapia
Plantas medicinales
Traditional Medicinal Plants as a Source of Inspiration for Osteosarcoma Therapy.
journal article
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URL
https://riuma.uma.es/bitstreams/86815e47-30db-42a1-921a-67e77c518213/download
File
MD5
5d3150a333bd62ae1fa2c12a8a6dc048
530437
application/pdf
Kazantseva Molecules_22.pdf