2026-05-28T13:32:19Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/305582026-02-03T11:27:00Zcom_10630_2254col_10630_37953

Multi-Omics Approach Reveals Prebiotic and Potential Antioxidant Effects of Essential Oils from the Mediterranean Diet on Cardiometabolic Disorder Using Humanized Gnotobiotic Mice. Sánchez-Quintero, María José Delgado, Josué Martín-Chaves, Laura Medina-Vera, Dina Murri, Mora Becerra-Muñoz, Víctor Manuel Estévez, Mario Crespo-Leiro, María G. Paz López, Guillermo González-Jiménez, Andrés García-Ranea, Juan Antonio Queipo-Ortuño, María Isabel Plaza-Andrades, Isaac Rodríguez Capitán, Jorge Pavón-Morón, Francisco Javier Jiménez-Navarro, Manuel Francisco Arterias coronaria - Enfermedades - Aspectos nutricionales Diabetes - Aspectos nutricionales Dieta - Mediterráneo (Región) Essential oils sourced from herbs commonly used in the Mediterranean diet have demonstrated advantageous attributes as nutraceuticals and prebiotics within a model of severe cardiometabolic disorder. The primary objective of this study was to assess the influences exerted by essential oils derived from thyme (Thymus vulgaris) and oregano (Origanum vulgare) via a comprehensive multi-omics approach within a gnotobiotic murine model featuring colonic microbiota acquired from patients diagnosed with coronary artery disease (CAD) and type-2 diabetes mellitus (T2DM). Our findings demonstrated prebiotic and potential antioxidant effects elicited by these essential oils. We observed a substantial increase in the relative abundance of the Lactobacillus genus in the gut microbiota, accompanied by higher levels of short-chain fatty acids and a reduction in trimethylamine N-oxide levels and protein oxidation in the plasma. Moreover, functional enrichment analysis of the cardiac tissue proteome unveiled an over-representation of pathways related to mitochondrial function, oxidative stress, and cardiac contraction. These findings provide compelling evidence of the prebiotic and antioxidant actions of thyme- and oregano-derived essential oils, which extend to cardiac function. These results encourage further investigation into the promising utility of essential oils derived from herbs commonly used in the Mediterranean diet as potential nutraceutical interventions for mitigating chronic diseases linked to CAD and T2DM. 2024-02-20T13:38:15Z 2024-02-20T13:38:15Z 2024-02-20T13:38:15Z 2023-08-20 journal article Sanchez-Quintero, M. J., Delgado, J., Chaves, L. M., Medina-Vera, D., Murri, M., Becerra‐Muñoz, V. M., Estévez, M., Crespo-Leiro, M. G., López, G. F., González-Jiménez, A., Ranea, J. A. G., Queipo-Ortuño, M. I., Plaza-Andrades, I., Rodríguez-Capitán, J., Pavón-Morón, F. J., & Jiménez‐Navarro, M. (2023). Multi-Omics Approach Reveals Prebiotic and Potential Antioxidant Effects of Essential Oils from the Mediterranean Diet on Cardiometabolic Disorder Using Humanized Gnotobiotic Mice. Antioxidants, 12(8), 1643. https://doi.org/10.3390/antiox12081643 https://hdl.handle.net/10630/30558 10.3390/antiox12081643 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI