2026-06-03T01:32:10Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/308582026-02-03T11:22:16Zcom_10630_2254col_10630_37953

Skin, gut, and lung barrier: physiological interface and target of intervention for preventing and treating allergic diseases Berni Canani, Roberto Caminati, Marco Carucci, Laura Eguiluz-Gracia, Ibón Alergia The epithelial barriers of the skin, gut, and respiratory tract are critical interfaces between the environment and the host, and they orchestrate both homeostatic and pathogenic immune responses. The mechanisms underlying epithelial barrier dys-function in allergic and inflammatory conditions, such as atopic dermatitis, food al-lergy, eosinophilic oesophagitis, allergic rhinitis, chronic rhinosinusitis, and asthma, are complex and influenced by the exposome, microbiome, individual genetics, and epigenetics. Here, we review the role of the epithelial barriers of the skin, digestive tract, and airways in maintaining homeostasis, how they influence the occurrence and progression of allergic and inflammatory conditions, how current treatments target the epithelium to improve symptoms of these disorders, and what the unmet needs are in the identification and treatment of epithelial disorders. 2024-03-19T11:23:23Z 2024-03-19T11:23:23Z 2024-03-19T11:23:23Z 2024-03-04 journal article Canani, R.B., Caminati, M., Carucci, L, & Eguiluz-Gracia, I. (2024). Skin, gut, and lung barrier: physiological interface and target of intervention for preventing and treating allergic diseases. Allergy, 1-16. DOI: 10.1111/all.16092 https://hdl.handle.net/10630/30858 10.1111/all.16092 eng http://creativecommons.org/licenses/by-nc/4.0/ open access Atribución-NoComercial 4.0 Internacional Wiley