2026-06-01T16:20:26Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/309332026-02-03T11:13:26Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Rasiel, Beltran-Casanueva
author
Aracelis, Hernández-García
author
Serrano-Castro, Pedro Jesús
author
Sánchez-Pérez, José Andrés
author
Barbancho-Fernández, Miguel Ángel
author
García-Casares, Natalia
author
Fuxe, Kjell
author
Borroto Escuela, Dasiel Óscar
author
Narváez-Peláez, Manuel
2024-04-08T10:55:16Z
2024-04-08T10:55:16Z
2024-04-15
Beltran-casanueva R, Hernández-García A, Serrano-Castro PJ, et al. Long-term enhancements in antidepressant efficacy and neurogenesis: Effects of intranasal co-administration of neuropeptide Y 1 receptor (NPY1R) and galanin receptor 2 (GALR2) agonists in the ventral hippocampus. The FASEB Journal. 2024; 38:e23595. doi:10.1096/fj.202400087R
https://hdl.handle.net/10630/30933
10.1096/fj.202400087R
This study evaluates the sustained antidepressant- like effects and neurogenic potential of a 3- day intranasal co- administration regimen of galanin receptor 2 (GALR2) agonist M1145 and neuropeptide Y Y1 receptor (NPY1R) agonist [Leu31, Pro34]NPY in the ventral hippocampus of adult rats, with outcomes ana-lyzed 3 weeks post- treatment. Utilizing the forced swimming test (FST), we found that this co- administration significantly enhances antidepressant- like behaviors, an effect neutralized by the GALR2 antagonist M871, highlighting the syner-gistic potential of these neuropeptides in modulating mood- related behaviors. In situ proximity ligation assay (PLA) indicated a significant increase in GALR2/NPYY1R heteroreceptor complexes in the ventral hippocampal dentate gyrus, suggesting a molecular basis for the behavioral outcomes observed. Moreover, proliferating cell nuclear antigen (PCNA) immunolabeling revealed increased cell proliferation in the subgranular zone of the dentate gyrus, specifically in neuroblasts as evidenced by co- labeling with doublecortin (DCX), without affect-ing quiescent neural progenitors or astrocytes. The study also noted a significant uptick in the number of DCX- positive cells and alterations in dendritic morphol-ogy in the ventral hippocampus, indicative of enhanced neuronal differentiation and maturation.
eng
Atribución-NoComercial-CompartirIgual 4.0 Internacional
Neurobiología del desarrollo
Antidepresivos
Long- term enhancements in antidepressant efficacy and neurogenesis: Effects of intranasal co- administration of neuropeptide Y 1 receptor (NPY1R) and galanin receptor 2 (GALR2) agonists in the ventral hippocampus
journal article
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URL
https://riuma.uma.es/bitstreams/30aa5e02-5e8f-4beb-959d-5a8b104c1f8d/download
File
MD5
16112812670fafb83d0b585ae81bc93c
4178497
application/pdf
The FASEB Journal - 2024 - Beltran‐casanueva - Long‐term enhancements in antidepressant efficacy and neurogenesis Effects.pdf