2026-06-02T14:39:28Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/311842026-02-03T11:17:10Zcom_10630_2254col_10630_37953

Pattern of recurrence of early breast cancer is different according to intrinsic subtype and proliferation index. Ribelles, Nuria Jerez-Aragonés, José Manuel Pajares, Bella Vicioso-Recio, Luis Prudencio Jiménez-Rodríguez, Begoña De Luque, Vanessa Franco, Leónardo Gallego-Domínguez, Elena María Márquez, Antonia Álvarez, Martina Sánchez-Muñoz, Alfonso Pérez-Rivas, Luis G. Alba-Conejo, Emilio Ribelles, Nuria Mamas - Cáncer - Recidiva Marcadores tumorales Articulo publicado en la revista Breast Cancer Research. Esta versión tiene Licencia Creative Commons CC-BY SÍ permite usos comerciales y SÍ permite obras derivadas Recurrence risk in breast cancer varies throughout the follow-up time. We examined if these changes are related to the level of expression of the proliferation pathway and intrinsic subtypes. Results: Luminal A displayed a slow risk increase, reaching its maximum after three years and then remained steady. Luminal B presented most of its relapses during the first five years. HER2-enriched tumors show a peak of recurrence nearly twenty months post-surgery, with a greater risk in Ki-67 ≥14%. However a second peak occurred at 72 months but the risk magnitude was greater in Ki-67 <14%. Triple negative tumors with low proliferation rate display a smooth risk curve, but with Ki-67 ≥14% show sharp peak at nearly 18 months. Conclusions: Each intrinsic subtype has a particular pattern of relapses over time which change depending on the level of activation of the proliferation pathway assessed by Ki-67. These findings could have clinical implications both on adjuvant treatment trial design and on the recommendations concerning the surveillance of patients. 2024-04-30T08:58:56Z 2024-04-30T08:58:56Z 2013-10-22 journal article Ribelles N, Perez-Villa L, Jerez JM, Pajares B, Vicioso L, Jimenez B, de Luque V, Franco L, Gallego E, Marquez A, Alvarez M, Sanchez-Muñoz A, Perez-Rivas L, Alba E. Pattern of recurrence of early breast cancer is different according to intrinsic subtype and proliferation index. Breast Cancer Res. 2013;15(5):R98. doi: 10.1186/bcr3559. PMID: 24148581; PMCID: PMC3978680. https://hdl.handle.net/10630/31184 doi: 10.1186/bcr3559 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional BMC