2026-06-06T03:51:58Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/316142026-02-03T11:26:21Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
González-García, Marta
author
Carrillo-Franco, Laura
author
Morales-Luque, Carmen
author
Ponce-Velasco, Marina
author
Gago-Calderón, Belén
author
Dawid-Milner, Marc Stefan
author
López-González, Manuel Víctor
2024-06-14T09:56:41Z
2024-06-14T09:56:41Z
2024
González-García, M., Carrillo-Franco, L., Morales-Luque, C. et al. Uncovering the neural control of laryngeal activity and subglottic pressure in anaesthetized rats: insights from mesencephalic regions. Pflugers Arch - Eur J Physiol (2024). https://doi.org/10.1007/s00424-024-02976-3
https://hdl.handle.net/10630/31614
10.1007/s00424-024-02976-3
To assess the possible interactions between the dorsolateral Periaqueductal Gray matter (dlPAG) and the laryngeal motor neurons of the nucleus Ambiguus (nA), we have examined the pattern of double staining c-Fos/FoxP2 protein immunoreactivity (c-Fos-ir/Fox-P2-ir) and Tyrosine Hydroxylase (TH) throughout the rostro-caudal extent of nA in spontaneously breathing anaesthetised male Sprague–Dawley rats during dlPAG electrical stimulation. Activation of the dlPAG elicited a selective increase in c-Fos-ir with an ipsilateral predominance in the somatas of the loose (p<0.05) and compact formation (p<0.01) within the nA and confirm the expression of FoxP2 bilaterally in all the domains within the nA. A second group of experiments was made to examine the importance of the dlPAG in modulating the laryngeal response evoked after electrical or chemical (glutamate) dlPAG stimulations. Both electrical and chemical stmulations evoked a significant decrease of laryngeal resistance (subglottal pressure) (p<0.001) accompanied with an increase in respiratory rate together with a pressor and tachycardic response. The results of our study contribute with new data on the role of the mesencephalic neuronal circuits in the control mechanisms of subglottic pressure and laryngeal activity.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Laringe
Neuronas motoras
Uncovering the neural control of laryngeal activity and subglottic pressure in anaesthetized rats: insights from mesencephalic regions.
journal article
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https://riuma.uma.es/bitstreams/e9fc13ce-e508-4925-8f73-4e67cce16201/download
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76f59c1dd31a3a92b329868dd57c5924
1855054
application/pdf
s00424-024-02976-3.pdf