2026-06-05T15:01:59Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/318762026-02-03T12:32:52Zcom_10630_2254col_10630_37959

Female microglia and neurogenesis respond differently to social defeat stress compared to males. Infantes-López, María Inmaculada Zambrana-Infantes, Emma Chaves-Peña, Patricia Nieto-Quero, Andrea Muñoz-Martín, José Zea-Doña, Alejandro Pedraza-Benítez, María del Carmen Pérez-Martín, Margarita Neurobiología del desarrollo Depresión mental - Diferencias sexuales Modelos animales en investigación Comunicación tipo póster a congreso internacional de la Federación Europea de Neurociencia. Depression is a concerning public health threat highly associated with stress. Stress increases brain immune alterations, namely in microglia, which can affect neuron physiology, like neurogenesis, causing a depressive-like behavior. However, despite depression being twice as frequent in females, most studies have been done in males. This results in a gap in our current understanding of stress processing in both sexes, and consequently in our current therapeutical approach. Here, we used the social defeat stress (SDS) paradigm in 8-week-old male and female C57BL/6J mice for 10 consecutive days. Anhedonic and social behavior were assessed to evaluate depressive-like traits. Using immunohistochemical and computer image analysis, microglial distribution, morphology, and neuronal maturation were analyzed in the dentate gyrus of the hippocampus. Results show a different response to SDS in both sexes. Microglial morphological activation was enhanced in the subgranular cell layer of the male dentate gyrus, yet it was not affected in females. In turn, both sexes showed lower neurogenesis, especially in the supra cell layer. Strikingly, female mice neurogenesis was affected in earlier stages of maturation, whereas males showed greater alteration in later maturation steps. In male mice, this impairment was statistically mediated by the microglia, unlike in females where microglia seemed unrelated. Also, males showed a deeper social disability, whereas females had a greater anhedonic profile. As a conclusion, female and male mice responding differently to stress proved that our current approach to depression might need to change to adapt to differential alterations in both sexes. 2024-07-04T08:53:01Z 2024-07-04T08:53:01Z 2024 conference output https://hdl.handle.net/10630/31876 eng FENS Forum 2024 Viena, Austria Junio 2024 http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional