2026-06-05T14:28:49Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/319602026-02-03T10:51:22Zcom_10630_2254col_10630_37953

Genomic variants association with selective hypersensitivityreactions to amoxicillin and clavulanic acid Nuñez, Rafael Fernández-Santamaría, Rubén Salas, María Bogas, Gador Diez-Echave, Patricia Mayorga Mayorga, Cristobalina Torres-Jaén, María Josefa Fernández-Duarte, Tahía Diana Alergia In summary, there are rare variants found in our patients that could be related to the development of AX or CLV- induced IDHRs. Interestingly, some of these rare variants could be associated with selective response to AX, such as the proapoptotic endonuclease ENDOG and neutrophil degranulation pathway, previously associ- ated with drug- induced anaphylaxis,6 or to CLV, like immunoprote- asome component PSMD8. Differences could be related to nature and metabolic characteristics of each drug; however, more research is needed. These findings represent a first step to identify potential genetic biomarkers to predict the susceptibility of suffering AX and CLV IDHRs. 2024-07-08T10:23:05Z 2024-07-08T10:23:05Z 2024-07-08T10:23:05Z 2024-06-29 journal article Nuñez, R., Fernandez-Santamaria, R., Salas, M., Bogas, G., Diez-Echave, P., Mayorga, C., Torres, M.J. and Fernandez, T.D. (2024), Genomic variants association with selective hypersensitivity reactions to amoxicillin and clavulanic acid. Allergy. https://hdl.handle.net/10630/31960 https://doi.org/10.1111/all.16229 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Wiley