2026-05-30T09:51:59Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/322362026-02-03T10:54:26Zcom_10630_2254col_10630_37953

Association between Cardiovascular Health, C-Reactive Protein, and Comorbidities in Spanish Urban-Dwelling Overweight/Obese Hypertensive Patients. Armas-Padrón, Ana María Sicilia-Sosvilla, Miriam Ruiz Esteban, Pedro Torres, Armando Hernández-Marrero, Domingo Presión sanguínea Sistema cardiovascular - Enfermedades Obesidad The relationship between poorer cardiovascular health metrics (CVHM) plus low-grade inflammation (LGI) and hypertension-mediated organ damage (HMOD) and hypertension-related comorbidities (HRC) in hypertensive populations with an overweight/obese (Ow/Ob) hypertensionrelated phenotype is understudied. We examined the relationship between the CVHM score and the presence of LGI and Ow/Ob hypertension-associated phenotype morbidities and mortality in 243 hypertensive patients from an urban primary care center. We recorded the baseline CVHM score plus clinical data, including hs-C-reactive protein (CRP) and prevalent and incident HMOD-HRC and death. A total of 26 (10.7%) had a body mass index (BMI) < 25 kg/m2, 95 (31.1%) were overweight (BMI 25–29.9 kg/m2), and 122 (50.2%) were obese (BMI 30 kg/m2). There were 264 cases of HMOD-HRC and 9 deaths. Higher hs-CRP levels were observed as BMI increased. Linear regression analysis showed a significant correlation between BMI and hs-CRP, adjusted for confounders. Additionally, individuals with a higher hs-CRP tertile had a significant increase in BMI. Significantly lower log hs-CRP levels were found as the number of ideal CVHM scores rose. Multivariate binary logistic regression found the risk of HMOD-HRC increased significantly as the ideal CVHM scores decreased, and hs-CRP levels also correlated with HMOD-HRC in the whole cohort and in the Ow and Ob subpopulations. These findings highlight the need for early intervention targeting ideal CVHMs among hypertensive individuals with an Ow/Ob phenotype in order to attenuate the inflammatory state and prevent cardiovascular disease. 2024-07-18T11:03:15Z 2024-07-18T11:03:15Z 2023-07-13 journal article Armas-Padrón, A. M., Sicilia-Sosvilla, M., Ruiz-Esteban, P., Torres, A., & Hernández, D. (2023). Association between Cardiovascular Health, C-Reactive Protein, and Comorbidities in Spanish Urban-Dwelling Overweight/Obese Hypertensive Patients. Journal Of Cardiovascular Development And Disease, 10(7), 300. https://doi.org/10.3390/jcdd10070300 https://hdl.handle.net/10630/32236 10.3390/jcdd10070300 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI