2026-06-06T19:31:39Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/322892026-02-03T10:58:10Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Rodríguez-Caso, Carlos Francisco
author
Montañez, Raúl
author
Cascante, Marta
author
Sánchez-Jiménez, Francisca María
author
Medina-Torres, Miguel Ángel
2024-07-24T11:07:50Z
2024-07-24T11:07:50Z
2006
https://hdl.handle.net/10630/32289
10.1074/jbc.M602756200
Polyamines are considered as essential compounds in living cells, since they are involved in cell proliferation, transcription,
and translation processes. Furthermore, polyamine homeostasis is necessary to cell survival, and its deregulation is involved in
relevant processes, such as cancer and neurodegenerative disorders. Great efforts have been made to elucidate the nature of
polyamine homeostasis, giving rise to relevant information concerning the behavior of the different components of polyamine
metabolism, and a great amount of information has been generated. However, a complex regulation at transcriptional, translational, and metabolic levels as well as the strong relationship between polyamines and essential cell processes make it difficult to discriminate the role of polyamine regulation itself from the whole cell response when an experimental approach is given in vivo. To overcome this limitation, a bottom-up approach to model mathematically metabolic pathways could allow us to elucidate the systemic behavior from individual kinetic and molecular properties. In this paper, we propose a mathematical model of polyamine metabolism from kinetic constants and both metabolite and enzyme levels extracted from bibliographic sources. This model captures the tendencies observed in transgenic mice for the so-called key enzymes of polyamine metabolism, ornithine decarboxylase, S-adenosylmethionine decarboxylase and spermine spermidine N-acetyl transferase. Furthermore, the model shows a relevant role of S-adenosylmethionine and acetyl-CoA availability in polyamine homeostasis, which are not usually considered in systemic experimental studies.
eng
Attribution 4.0 Internacional
Poliaminas - Metabolismo
Cáncer - Investigación
Mathematical Modeling of Polyamine Metabolism in Mammals.
journal article
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URL
https://riuma.uma.es/bitstreams/ffac8ed3-33b0-4ea2-a6d8-9ef05f140688/download
File
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96a16df1f76a45f450b68a6cc96e138e
998688
application/pdf
JBC.pdf