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00925njm 22002777a 4500 dc Cobo-Vuilleumier, Nadia author Lorenzo, Petra I author García Rodríguez, Noelia author Herrera Gómez, Irene de Gracia author Fuente-Martin, Esther author López-Noriega, Livia author Mellado-Gil, José Manuel author Romero-Zerbo, Silvana Yanina author Baquié, Mathurin author Lachaud, Christian Claude author Stifter, Katja author Perdomo, German author Bugliani, Marco author De Tata, Vincenzo author Bosco, Domenico author Parnaud, Geraldine author Pozo, David author Hmadcha, Abdelkrim author Florido, Javier P author Toscano, Miguel G author de Haan, Peter author Schoonjans, Kristina author Sánchez Palazón, Luis author Marchetti, Piero author Schirmbeck, Reinhold author Martín-Montalvo, Alejandro author Meda, Paolo author Bernat, Soria author Bermúdez Silva, Francisco Javier author St-Onge, Luc author Gauthier, Benoit R author 2018 Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited clinical efficacy. Therefore, it is timely to identify innovative targets to dampen the immune process, while promoting beta cell survival and function. Liver receptor homologue-1 (LRH-1) is a nuclear receptor that represses inflammation in digestive organs, and protects pancreatic islets against apoptosis. Here, we show that BL001, a small LRH-1 agonist, impedes hyperglycemia progression and the immune-dependent inflammation of pancreas in murine models of T1DM, and beta cell apoptosis in islets of type 2 diabetic patients, while increasing beta cell mass and insulin secretion. Thus, we suggest that LRH-1 agonism favors a dialogue between immune and islet cells, which could be druggable to protect against diabetes mellitus. Cobo-Vuilleumier, N., Lorenzo, P.I., Rodríguez, N.G. et al. LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus. Nat Commun 9, 1488 (2018). https://doi.org/10.1038/s41467-018-03943-0 https://hdl.handle.net/10630/32312 10.1038/s41467-018-03943-0 Diabetes LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus