2026-06-01T14:10:18Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/323222026-02-03T10:59:11Zcom_10630_2254col_10630_37953

Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling Garcia Diaz, Beatriz Bachelin, Corinne Coulpier, Fanny Gerschenfeld, Gaspar Deboux, Cyrille Zujovic, Violetta Charnay, Patrick Topilko, Piotr Baron Van Evercooren, Anne Sistema nervioso central Schwann cells (SC) enter the central nervous system (CNS) in pathophysiological conditions. However, how SC invade the CNS to remyelinate central axons remains undetermined. We studied SC migratory behavior ex vivo and in vivo after exogenous transplantation in the demyelinated spinal cord. The data highlight for the frst time that SC migrate preferentially along blood vessels in perivascular extracellular matrix (ECM), avoiding CNS myelin. We demonstrate in vitro and in vivo that this migration route occurs by virtue of a dual mode of action of Eph/ephrin signaling. Indeed, EphrinB3, enriched in myelin, interacts with SC Eph receptors, to drive SC away from CNS myelin, and triggers their preferential adhesion to ECM components, such as fbronectin via integrinβ1 interactions. This complex interplay enhances SC migration along the blood vessel network and together with lesion-induced vascular remodeling facilitates their timely invasion of the lesion site. These novel fndings elucidate the mechanism by which SC invade and contribute to spinal cord repair. 2024-07-26T09:25:25Z 2024-07-26T09:25:25Z 2019 journal article Garcia-Diaz, B., Bachelin, C., Coulpier, F. et al. Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling. Acta Neuropathol 138, 457–476 (2019). https://doi.org/10.1007/s00401-019-02011-1 https://hdl.handle.net/10630/32322 10.1007/s00401-019-02011-1 eng open access Springer Link