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oai:riuma.uma.es:10630/323742026-02-03T11:30:51Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Romero-Zerbo, Silvana Yanina author Decara, Juan author El Bekay Rizky, Rajaa author Sánchez-Salido, Lourdes author Del Arco-Herrera, Ignacio author Rodriguez-de-Fonseca, Fernando author De-Diego-Otero, María Yolanda author 2009 Fragile X syndrome is the most common form of inherited mentalretardation. It is typically caused by a mutation of the Fragile X mental-retardation 1 (Fmr1) gene. To better understand the role of the Fmr1 geneand its gene product, the fragile X mental-retardation protein in centralnervous system functions, an fmr1 knockout mouse that is deficient in thefragile X mental-retardation protein was bred. In the present study, fragile Xmental retardation 1-knockout and wild-type mice are used to determinebehaviour and oxidative stress alterations, including reduced glutathione,oxidized glutathione and thiobarbituric acid-reactive substances, before andafter chronic treatment with melatonin or tianeptine. Reduced glutathionelevels were reduced in the brain of fmr1-knockout mice and chronicmelatonin treatment normalized the glutathione levels compared withthe control group. Lipid peroxidation was elevated in brain and testes offmr1-knockout mice and chronic melatonin treatment prevents lipidperoxidation in both tissues. Interestingly, chronic treatment with melatoninalleviated the altered parameters in the fmr1-knockout mice, includingabnormal context-dependent exploratory and anxiety behaviours andlearning abnormalities. Chronic treatment with tianeptine (a serotoninreuptake enhancer) did not normalize the behaviour in fmr1-knockout mice.The prevention of oxidative stress in the fragile X mouse model, by anantioxidant compound such as melatonin, emerges as a new and promisingapproach for further investigation on treatment trials for the disease Romero-Zerbo, Y., Decara, J., El Bekay, R., Sanchez-Salido, L., Del Arco-Herrera, I., De Fonseca, F.R. and De Diego-Otero, Y. (2009), Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome. Journal of Pineal Research, 46: 224-234. https://doi.org/10.1111/j.1600-079X.2008.00653.x https://hdl.handle.net/10630/32374 10.1111/j.1600-079X.2008.00653.x Melatonina Sistema nervioso central Estrés oxidativo Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome