2026-05-28T22:45:46Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/323752026-02-03T10:51:11Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Marco, Eva-María
author
Romero-Zerbo, Silvana Yanina
author
Paz Viveros, María
author
Bermúdez Silva, Francisco Javier
2024-07-31T08:56:14Z
2024-07-31T08:56:14Z
2012
Marco, Eva M.a; Romero-Zerbo, Silvana Y.b,c; Viveros, María-Paza; Bermudez-Silva, Francisco J.b,c. The role of the endocannabinoid system in eating disorders: pharmacological implications. Behavioural Pharmacology 23(5 and 6):p 526-536, September 2012. | DOI: 10.1097/FBP.0b013e328356c3c9
https://hdl.handle.net/10630/32375
10.1097/FBP.0b013e328356c3c9
The endocannabinoid (eCB) system is a widespread intercellular signalling mechanism that plays a critical role in body homoeostasis. It is located in key points involved in food intake and energy expenditure, coordinating all the players involved in energy balance. As such, it has come to be seen as an interesting target for the management of diseases characterized by an imbalanced energy homoeostasis, such as obesity and eating disorders. The aetiology of eating disorders and the molecular systems involved are still largely a mystery. Research has focused on brain circuits where the eCB system plays an important role, such as those related to feeding behaviour and the rewarding properties of food. Accordingly, recent findings have suggested a deregulation of the eCB system in eating disorders. At present, cannabinoid agonists are safe and effective tools in the management of diseases in which weight gain is needed, for example cachexia in AIDS patients. However, studies on the potential therapeutic validity of cannabinoids in eating disorders are scarce and inconclusive. Taken together, all these considerations warrant more preclinical and clinical investigations in the role of the eCB system in eating disorders. Eventually, they may provide novel pharmacological approaches for the treatment of these diseases.
eng
Atribución 4.0 Internacional
Anorexia nerviosa
Bulimia
The role of the endocannabinoid system in eating disorders: pharmacological implications
journal article
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URL
https://riuma.uma.es/bitstreams/9b28def2-ce9e-4230-a308-a66e7d31d235/download
File
MD5
a2f48928d6d4b6f01197fe9d9b96e5f6
331116
application/pdf
The role of the ECS in eating disorders 2012a.pdf