2026-05-30T04:13:50Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/327032026-02-03T11:10:59Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Yu, Daqi author Ren, Yandong author Uesaka, Masahiro author Beavan, Alan J. S. author Muffato, Matthieu author Shen, Jieyu author Li, Yongxin author Sato, Iori author Wan, Wenting author Clark, James W. author Keating, Joseph N. author Carlisle, Emily M. author Dearden, Richard P. author Giles, Sam author Randle, Emma author Sansom, Robert S. author Feuda, Roberto author Fleming, James F. author Sugahara, Fumiaki author Cummins, Carla author Patricio, Mateus author Akanni, Wasiu author D'Aniello, Salvatore author Bertolucci, Cristiano author Irie, Naoki author Alev, Cantas author Sheng, Guojun author de Mendoza, Alex author Maeso, Ignacio author Irimia, Manuel author Fromm, Bastian author Peterson, Kevin J. author Das, Sabyasachi author Hirano, Masayuki author Rast, Jonathan P. author Cooper, Max D. author Paps, Jordi author Pisani, Davide author Kuratani, Shigeru author Martin, Fergal J. author Wang, Wen author Donoghue, Philip C. J. author Zhang, Yong E. author Pascual-Anaya, Juan author 2024-03 Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and is often assumed to be causally associated with organismal innovations and radiations. The 2R hypothesis suggests that two WGD events (1R and 2R) occurred during early vertebrate evolution. However, the timing of the 2R event relative to the divergence of gnathostomes ( jawed vertebrates) and cyclostomes ( jawless hagfishes and lampreys) is unresolved and whether these WGD events underlie vertebrate phenotypic diversification remains elusive. Here we present the genome of the inshore hagfish, Eptatretus burgeri. Through comparative analysis with lamprey and gnathostome genomes, we reconstruct the early events in cyclostome genome evolution, leveraging insights into the ancestral vertebrate genome. Genome-wide synteny and phylogenetic analyses support a scenario in which 1R occurred in the vertebrate stem-lineage during the early Cambrian, and 2R occurred in the gnathostome stem-lineage, maximally in the late Cambrian–earliest Ordovician, after its divergence from cyclostomes. We find that the genome of stem-cyclostomes experienced an additional independent genome triplication. Functional genomic and morphospace analyses demonstrate that WGD events generally contribute to developmental evolution with similar changes in the regulatory genome of both vertebrate groups. However, appreciable morphological diversification occurred only in the gnathostome but not in the cyclostome lineage, calling into question the general expectation that WGDs lead to leaps of bodyplan complexity. u, D., Ren, Y., Uesaka, M. et al. Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences. Nat Ecol Evol 8, 519–535 (2024). https://doi.org/10.1038/s41559-023-02299-z https://hdl.handle.net/10630/32703 10.1038/s41559-023-02299-z Vertebrados - Evolución Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences