2026-06-05T15:56:43Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/330892026-02-03T11:24:46Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Leiva Rebollo, Rocío
author
Castro-López, María Dolores
author
Moreno García, Patricia
author
Borrego-García, Juan José
author
Labella Vera, Alejandro Manuel
2024-09-24T16:24:54Z
2024-09-24T16:24:54Z
2021-05-29
Leiva-Rebollo, R.; Castro, D.; Moreno, P.; Borrego, J.J.; Labella, A.M. Evaluation of Gilthead Seabream (Sparus aurata) Immune Response after LCDV-Sa DNA Vaccination. Animals 2021, 11, 1613. https://doi.org/10.3390/ani11061613
https://hdl.handle.net/10630/33089
10.3390/ani11061613
Lymphocystis disease is the main viral pathology in gilthead seabream aquaculture. Currently, there are no treatments or vaccines to control this disease, thus our main goal was to construct a DNA vaccine that can be used in the future to stop the spread of this pathology in sea farms. The vaccine consisted of a plasmid DNA that contains a known viral gene. Once it was established that the vaccine drives the expression of the antigenic viral protein in fish, vaccination experiments were conducted to determine if the vaccinated fish become protected against the viral infection. In addition, the immune response triggered by the vaccine was also evaluated in order to understand the mechanisms underlying such protection. The obtained results showed that in vaccinated fish an activation of several genes relating to both the inflammatory process and the mucosal immunity were produced, as well as specific anti-viral antibodies. Although limited, our results deserve further investigation to assess the efficacy of the vaccine in bigger fish populations and to confirm the mode of action of the vaccine.
eng
Atribución 4.0 Internacional
Inmunología
Evaluation of Gilthead Seabream (Sparus aurata) Immune Response after LCDV-Sa DNA Vaccination
journal article
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URL
https://riuma.uma.es/bitstreams/a929e753-aa17-463a-b7a0-138e963873b8/download
File
MD5
e11b375ba4ba9172c0dc39473a94ce09
3696288
application/pdf
animals-11-01613-v2.pdf