2026-05-31T10:35:41Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/331772026-02-03T10:49:27Zcom_10630_2254col_10630_37953

López-Bueno, Alberto Mavian, Carla Labella Vera, Alejandro Manuel Castro, Dolores Borrego, Juan José Alcami, Antonio Alejo, Alí 2024-09-25T09:30:10Z 2024-09-25T09:30:10Z 2016-09-12 López-Bueno A, Mavian CLabella AM, Castro D, Borrego JJ, Alcami A, Alejo A. 2016. Concurrence of Iridovirus, Polyomavirus, and a Unique Member of a New Group of Fish Papillomaviruses in Lymphocystis Disease-Affected Gilthead Sea Bream. J Virol 90:. https://doi.org/10.1128/jvi.01369-16 https://hdl.handle.net/10630/33177 https://doi.org/10.1128/jvi.01369-16 Lymphocystis disease is a geographically widespread disease affecting more than 150 different species of marine and freshwater fish. The disease, provoked by the iridovirus lymphocystis disease virus (LCDV), is characterized by the appearance of papillomalike lesions on the skin of affected animals that usually self-resolve over time. Development of the disease is usually associated with several environmental factors and, more frequently, with stress conditions provoked by the intensive culture conditions present in fish farms. In gilthead sea bream (Sparus aurata), an economically important cultured fish species in the Mediterranean area, a distinct LCDV has been identified but not yet completely characterized. We have used direct sequencing of the virome of lymphocystis lesions from affected S. aurata fish to obtain the complete genome of a new LCDV-Sa species that is the largest vertebrate iridovirus sequenced to date. Importantly, this approach allowed us to assemble the full-length circular genome sequence of two previously unknown viruses belonging to the papillomaviruses and polyomaviruses, termed Sparus aurata papillomavirus 1 (SaPV1) and Sparus aurata polyomavirus 1 (SaPyV1), respectively. Epidemiological surveys showed that lymphocystis disease was frequently associated with the concurrent appearance of one or both of the new viruses. SaPV1 has unique characteristics, such as an intron within the L1 gene, and as the first member of the Papillomaviridae family described in fish, provides evidence for a more ancient origin of this family than previously thought. eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Peces - Enfermedades por virus Concurrence of Iridovirus, Polyomavirus, and a Unique Member of a New Group of Fish Papillomaviruses in Lymphocystis Disease-Affected Gilthead Sea Bream journal article