2026-06-01T02:46:14Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/333682026-02-03T11:07:17Zcom_10630_2254col_10630_37953

Analytical methodologies for the determination of cisplatin Espinosa-Bosch, Maria Ruiz-Sánchez, Antonio Jesús Sánchez-Rojas, María Fuensanta Bosch-Ojeda, Catalina Cáncer - Tratamiento cis-Diamminedichloroplatinum(II) (cisplatin) is a important chemotherapeutic drug for cancer treatment since 1978. Unfortunately, because of the severe side-effects like nephrotoxicity, ototoxicity, etc., they are administered in small doses at low concentration establishing the maximum limit dosage to 100 mg/m2 (21 days). A variety of analytical methods have been proposed for the determination of cisplatin in biological fluids and tissues that permit the accurate determination at or below the part per billion level in the native sample. The purpose of the current review is to provide a systematic survey of the latest analytical techniques for the determination of cisplatin in biological samples. 2024-09-26T08:19:29Z 2024-09-26T08:19:29Z 2008 2008-07-15 journal article M. Espinosa Bosch, A.J. Ruiz Sánchez, F. Sánchez Rojas, C. Bosch Ojeda, Analytical methodologies for the determination of cisplatin, Journal of Pharmaceutical and Biomedical Analysis, Volume 47, Issue 3, 2008, Pages 451-459, ISSN 0731-7085, https://doi.org/10.1016/j.jpba.2008.01.047. https://hdl.handle.net/10630/33368 10.1016/j.jpba.2008.01.047 eng open access ScienceDirect