2026-05-27T04:50:15Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/334952026-02-03T11:23:26Zcom_10630_2254col_10630_37953

Lozano-Lorca, Macarena Muñoz-Bravo, Carlos Barrios-Rodríguez, Rocío Castillo-Hermoso, María Ángeles Kouiti, Malak González-Palacios Torres, Carla Jiménez-Moleón, José Juan Olmedo-Requena, Rocío 2024-09-26T12:33:08Z 2024-09-26T12:33:08Z 2024 https://hdl.handle.net/10630/33495 https://doi.org/10.3390/nu16060836 Acrylamide is a probable carcinogen. Its main sources are the diet and tobacco. The association between acrylamide intake from the diet and tobacco and prostate cancer (PCa) has not been previously evaluated. We aimed to evaluate the relationship between dietary acrylamide intake and exposure to acrylamide through cigarettes and PCa risk. A population-based case–control (CAPLIFE) study was conducted, including 428 incident PCa cases and 393 controls. Smoking and dietary information, with a validated food frequency questionnaire, was collected. We calculated the amount of acrylamide from both sources, and tertiles (Ts) were created. Multivariable logistic regression and restricted cubic spline models were applied to assess the association between exposure to acrylamide and PCa risk. The median was similar for acrylamide in both dietary and smoking acrylamide among PCa cases and controls. No association was observed between dietary acrylamide intake and overall PCa risk (adjusted ORT3vsT1 = 0.90 (95% CI 0.59, 1.37)). A risk trend was observed for acrylamide exposure from cigarette smoking (p-trend = 0.032), with the highest odds in those subjects with the high exposure to acrylamide through cigarettes (adjusted ORT3vsT1 = 1.67 (95% CI 0.92, 3.04)). The restricted cubic splines suggested a linear relationship. In conclusion, acrylamide from smoking could be positively associated with PCa risk, but no association was observed for dietary acrylamide. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Dieta Tabaquismo Dietary and Smoking Acrylamide and Prostate Cancer Risk: CAPLIFE Study journal article