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Caramés-Tejedor, José María Pérez-Montoyo, Elena García-Hernández, Raquel Canals-Gamoneda, Santiago 2024-09-27T06:49:29Z 2024-09-27T06:49:29Z 2020-07-14 Caramés, J. M., Pérez-Montoyo, E., Garcia-Hernandez, R., & Canals, S. (2020). Hippocampal dentate gyrus coordinates brain-wide communication and memory updating through an inhibitory gating. BioRxiv, 2020.07.14.202218. https://hdl.handle.net/10630/33556 10.1101/2020.07.14.202218 Distinct forms of memory processing are often causally identified with specific brain regions, but a key facet of memory processing includes linking separated neuronal populations. Using cell-specific manipulations of inhibitory neuronal activity, we discovered a key role of the dentate gyrus (DG) in coordinating dispersed neuronal populations during memory formation. In whole-brain fMRI and electrophysiological experiments, we found that parvalbumin (PV) interneurons in the DG control the functional coupling of the hippocampus within a wider network of neocortical and subcortical structures including the prefrontal cortex (PFC) and the nucleus accumbens (NAc). In a novel object-location task, regulation of PV interneuron activity enhanced or prevented memory encoding and, without effect upon the total number of task activated c-Fos+ cells, revealed a correlation between activated neuronal populations in the hippocampus-PFC-NAc network. These data suggest a critical regulatory role of PV interneurons in the dentate gyrus in brain-wide polysynaptic communication channels and the association of cell assemblies across multiple brain regions. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Hipocampo (Cerebro) Memoria Hippocampal dentate gyrus coordínales brain-wide communication and memory updating through an inhibitory gating. journal article