2026-05-31T13:37:00Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/336392026-02-03T10:49:35Zcom_10630_2254col_10630_37953

Redondo-Bautista, Maximino Funez, Rafael Medina Cano, Francisco José Rodrigo, Isabel Acebal-Blanco, María Mercedes Téllez-Santana, Teresa Roldán Cardenete, María José Hortas Nieto, María Luisa Bellinvia, Ana Pereda, Teresa Domingo, Laia Morales-Suárez-Varela, María Manuela Sala, Maria Rueda-Domínguez, Antonio 2024-09-27T09:48:09Z 2024-09-27T09:48:09Z 2012 Redondo M, Funez R, Medina-Cano F, Rodrigo I, Acebal M, Tellez T, Roldan MJ, Hortas ML, Bellinvia A, Pereda T, Domingo L, Morales-Suarez Varela M, Sala M, Rueda A. Detection methods predict differences in biology and survival in breast cancer patients. BMC Cancer. 2012 Dec 17;12:604. doi: 10.1186/1471-2407-12-604. PMID: 23244222; PMCID: PMC3541058. https://hdl.handle.net/10630/33639 10.1186/1471-2407-12-604 Background: The aim of this study was to measure the biological characteristics involved in tumorigenesis and the progression of breast cancer in symptomatic and screen-detected carcinomas to identify possible differences. Methods: For this purpose, we evaluated clinical-pathological parameters and proliferative and apoptotic activities in a series of 130 symptomatic and 161 screen-detected tumors. Results: After adjustment for the smaller size of the screen-detected carcinomas compared with symptomatic cancers, those detected in the screening program presented longer disease-free survival (RR = 0.43, CI = 0.19-0.96) and had high estrogen and progesterone receptor concentrations more often than did symptomatic cancers (OR = 3.38, CI = 1.72-6.63 and OR = 3.44, CI = 1.94-6.10, respectively). Furthermore, the expression of bcl-2, a marker of good prognosis in breast cancer, was higher and HER2/neu expression was lower in screen-detected cancers than in symptomatic cancers (OR = 1.77, CI = 1.01-3.23 and OR = 0.64, CI = 0.40-0.98, respectively). However, when comparing prevalent vs incident screen-detected carcinomas, prevalent tumors were larger (OR = 2.84, CI = 1.05-7.69), were less likely to be HER2/neu positive (OR = 0.22, CI = 0.08-0.61) and presented lower Ki67 expression (OR = 0.36, CI = 0.17-0.77). In addition, incident tumors presented a shorter survival time than did prevalent ones (RR = 4.88, CI = 1.12-21.19). Conclusions: Incident carcinomas include a variety of screen-detected carcinomas that exhibit differences in biology and prognosis relative to prevalent carcinomas. The detection method is important and should be taken into account when making therapy decisions. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Mamas - Cáncer Detection methods predict differences in biology and survival in breast cancer patients journal article