2026-06-06T04:36:52Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/337002026-02-03T10:52:42Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Ruiz-Villalba, Adrián
author
Hoppler, Stefan
author
van den Hoff, Maurice JB
author
van den hoff
2024-09-27T11:06:20Z
2024-09-27T11:06:20Z
2016
https://hdl.handle.net/10630/33700
10.1002/dvdy.24372
Wnt signaling plays an essential role in development and differentiation. Heart development is initiated with the induction of precardiac mesoderm requiring the tightly and spatially controlled regulation of canonical and noncanonical Wnt signaling pathways. The role of Wnt signaling in subsequent development of the heart fields is to a large extent unclear. We will discuss the role of Wnt signaling in the development of the arterial and venous pole of the heart, highlighting the dual roles of Wnt signaling with respect to its time- and dosage-dependent effects and the balance between the canonical and noncanonical signaling. Canonical signaling appears to be involved in retaining the cardiac precursors in a proliferative and precursor state, whereas noncanonical signaling promotes their differentiation. Thereafter, both canonical and noncanonical signaling regulate specific steps in differentiation of the cardiac compartments. Because heart development is a contiguous, rather than a sequential, process, analyses tend only to show a single timeframe of development. The repetitive alternating and reciprocal effect of canonical and noncanonical signaling is lost when studied in homogenates. Without the simultaneous in vivo visualization of the different Wnt signaling pathways, the mechanism of Wnt signaling in heart development remains elusive.
eng
Sistema cardiovascular -- Enfermedades
Sistema cardiovascular
Wnt signaling in the heart fields: Variations on a common theme
journal article
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Ruiz-Villalba et al, 2016.pdf