2026-05-31T17:04:14Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/337682026-02-03T10:58:04Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Vida-Pol, Yolanda author Collado-Martín, Daniel author Nájera-Albendín, Francisco author Claros-Gil, Silvia author Becerra-Ratia, José author Andrades-Gómez, José Antonio author Pérez-Inestrosa, Ezequiel author 2016-05-17 Mesenchymal stem cells (MSCs) are promising candidates for a range of tissue regeneration applications. Adequate scaffolds are necessary for their application in vivo, where interactions between cells and the surface material are critical. Arginine-glycine-aspartic acid tripeptides (RGD) were conjugated to polyamidoamine (PAMAM) dendrimers and used to pre-treat test surfaces. We demonstrate that pretreatment with dendrimer-presented tripeptides efficiently increases MSC adhesion to a polystyrene test surface, and that treatment effectiveness is related to how tripeptides are presented by the dendrimer to the cell. We tested both R-G-D–dendrimer and dendrimer–R-G-D arrangements and found the former to be optimal in terms of surface adhesion. https://hdl.handle.net/10630/33768 10.1039/C6RA06177J Células madre Dendrimer surface orientation of the RGD peptide affects mesenchymal stem cell adhesion.