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oai:riuma.uma.es:10630/339162026-02-03T11:35:18Zcom_10630_2254col_10630_37953

00925njm 22002777a 4500 dc Suardíaz García, Margarita author Clemente, Diego author Marín Bañasco, Carmen author Órpez, Teresa author Hurtado-Guerrero, Isaac author Pavía-Molina, José author Pinto-Medel, Maria Jesús author De Castro, Fernando author Leyva-Fernández, Laura author Fernández Fernández, Óscar author Oliver-Martos, Begoña author 2016 Endogenous interferon beta (IFNβ) is an important cytokine involved in several chronic inflammatory diseases, such as Multiple Sclerosis (MS). In spite of the numerous therapeutic approaches available for MS patients, the administration of recombinant IFNβ continues being one of the first line treatment to these patients. The soluble form of IFNβ receptor (sIFNAR2) could act as critical regulator of the endogenous and the systemically administered IFNβ, but whether it functions as an agonist or antagonist of its ligand is not completely elucidated. Morover, the possible role of sIFNAR2 in autoimmune diseases like MS is still unknown and so far overlooked. Here we evaluated the efficacy of the combined therapy of IFNβ and our recombinant protein analogous to human sIFNAR2 as a treatment in a chronic mice model of MS (CP-EAE). We also tested the effect of the sIFNAR2 administered as a monotherapy over these EAE-animals. The results showed that our recombinant sIFNAR2 protein potentiates the immunomodulatory effects of exogenous IFNβ in CP-EAE by increasing the reduction of the induced inflammation and the tissue damage. Furthermore, we demonstrate for the first time that sIFNAR2 shows intrinsic properties by modulating the CP-EAE progression and the neuroinflammation processes related to this disease. Another intrinsic activity showed by sIFNAR2 is the inhibition of the T cells proliferation, which increase its potential as therapeutic molecule. Suardíaz M, Clemente D, Marin-Bañasco C, Orpez T, Hurtado-Guerrero I, Pavía J, Pinto-Medel MJ, De Castro F, Leyva L, Fernández O, Oliver B. Recombinant soluble IFN receptor (sIFNAR2) exhibits intrinsic therapeutic efficacy in a murine model of Multiple Sclerosis. Neuropharmacology. 2016 Nov;110(Pt A):480-492. doi: 10.1016/j.neuropharm.2016.07.026. Epub 2016 Jul 22. PMID: 27452720. https://hdl.handle.net/10630/33916 10.1016/j.neuropharm.2016.07.026 Esclerosis múltiple Recombinant soluble IFN receptor (sIFNAR2) exhibits intrinsic therapeutic efficacy in a murine model of Multiple Sclerosis