2026-05-31T14:30:30Zhttps://riuma.uma.es/rest/oai/request

oai:riuma.uma.es:10630/339932026-02-03T10:53:08Zcom_10630_2254col_10630_37953

Clemente-Postigo, María Mercedes Queipo-Ortuño, María Isabel Murri, Mora Boto-Ordóñez, María Pérez-Martínez, Pablo Andrés-Lacueva, Cristina Cardona-Díaz, Fernando Tinahones-Madueño, Francisco José 2024-09-30T09:55:03Z 2024-09-30T09:55:03Z 2012 Clemente-Postigo, M. et al. (2012). Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients. Journal of Lipid Research, 53 (5), 973 - 978. DOI 10.1194/jlr.P020909 https://hdl.handle.net/10630/33993 10.1194/jlr.P020909 The low-grade inflammation observed in obesity has been associated with a high-fat diet, though this relation is not fully understood. Bacterial endotoxin, produced by gut microbiota, may be the linking factor. However, this has not been confirmed in obese patients. To study the relationship between a high-fat diet and bacterial endotoxin, we analyzed postprandial endotoxemia in morbidly obese patients after a fat overload. The endotoxin levels were determined in serum and the chylomicron fraction at baseline and 3 h after a fat overload in 40 morbidly obese patients and their levels related with the degree of insulin resistance and postprandial hypertriglyceridemia. The morbidly obese patients with the highest postprandial hypertriglyceridemia showed a significant increase in lipopolysaccharide (LPS) levels in serum and the chylomicron fraction after the fat overload. Postprandial chylomicron LPS levels correlated positively with the difference between postprandial triglycerides and baseline triglycerides. There were no significant correlations between C-reactive protein (CRP) and LPS levels. The main variables contributing to serum LPS levels after fat overload were baseline and postprandial triglyceride levels but not glucose or insulin resistance. Additionally, superoxide dismutase activity decreased significantly after the fat overload. Postprandial LPS increase after a fat overload is related to postprandial hypertriglyceridemia but not to degree of insulin resistance in morbidly obese patients. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Lípidos - Metabolismo - Alteraciones Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients journal article