2026-06-02T08:31:18Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/340102026-02-03T10:59:24Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Carmona-Mejías, Rita María
author
Guadix, JA
author
Cano, E
author
Portillo-Sánchez, V
author
Pérez-Pomares, JM
author
Muñoz-Chápuli, R
2024-09-30T10:33:49Z
2024-09-30T10:33:49Z
2010-08
Carmona, R., Guadix, J.A., Cano, E., Ruiz-Villalba, A., Portillo-Sánchez, V., Pérez-Pomares, J.M. and Muñoz-Chápuli, R. (2010), The embryonic epicardium: an essential element of cardiac development. Journal of Cellular and Molecular Medicine, 14: 2066-2072. https://doi.org/10.1111/j.1582-4934.2010.01088.x
https://hdl.handle.net/10630/34010
10.1111/j.1582-4934.2010.01088.x
The epicardium has recently been identified as an active and essential element of cardiac development. Recent reports have unveiled a variety of functions performed by the embryonic epicardium, as well as the cellular and molecular mechanisms regulating them. However, despite its developmental importance, a number of unsolved issues related to embryonic epicardial biology persist. In this review, we will summarize our current knowledge about (i) the ontogeny and evolution of the epicardium, including a discussion on the evolutionary origins of the proepicardium (the epicardial primordium), (ii) the nature of epicardial–myocardial interactions during development, known to be essential for myocardial growth and maturation, and (iii) the contribution of epicardially derived cells to the vascular and connective tissue of the heart. We will finish with a note on the relationships existing between the primordia of the viscera and their coelomic epithelial lining. We would like to suggest that at least a part of the properties of the embryonic epicardium are shared by many other coelomic cell types, such that the role of epicardium in cardiac development is a particular example of a more general mechanism for the contribution of coelomic and coelomic-derived cells to the morphogenesis of organs such as the liver, kidneys, gonads or spleen.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Corazón - Enfermedades
The embryonic epicardium: an essential element of cardiac development
journal article
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2010 - Carmona - JCMM - Review.pdf