2026-05-30T07:31:48Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/340332026-02-03T10:52:12Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Cano-Rincón, Elena
author
Schwarzkopf, Jennifer
author
Kanda, Masatoshi
author
Lindberg, Eric
author
Hollfinger, Irene
author
Pogontke Díaz, Cristina
author
Braeuning, Caroline
author
Fischer, Cornelius
author
Hübner, Norbert
author
Gerhardt, Holger
2024-09-30T11:22:01Z
2024-09-30T11:22:01Z
2024
https://hdl.handle.net/10630/34033
10.1161/CIRCRESAHA.124.324868
The elaborate patterning of coronary arteries critically supports the high metabolic activity of the beating heart. How coronary endothelial cells coordinate hierarchical vascular remodeling and achieve arteriovenous specification remains largely unknown. Understanding the molecular and cellular cues that pattern coronary arteries is crucial to develop innovative therapeutic strategies that restore functional perfusion within the ischemic heart.
Results: We discover that coronary arteries originate from cells that have previously transitioned through a specific tip cell phenotype. We identify nonoverlapping intramyocardial and subepicardial tip cell populations with differential gene expression profiles and regulatory pathways. Esm1-lineage tracing confirmed that intramyocardial tip cells selectively contribute to coronary arteries and endocardial tunnels, but not veins. Notably, prearterial cells are detected from development stages to adulthood, increasingly in response to ischemic injury, and in human embryos, suggesting that tip cell-to-artery specification is a conserved mechanism.
Conclusions: A tip cell-to-artery specification mechanism drives arterialization of the intramyocardial plexus and endocardial tunnels throughout life and is reactivated upon ischemic injury. Differential sprouting programs govern the formation and specification of the venous and arterial coronary plexus.
eng
Attribution 4.0 Internacional
Arterias coronarias
Intramyocardial Sprouting Tip Cells Specify Coronary Arterialization.
journal article
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URL
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1e776e5c937dd2b718bdc2283427316e
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cano-et-al-2024-intramyocardial-sprouting-tip-cells-specify-coronary-arterialization.pdf