2026-06-03T14:37:43Zhttps://riuma.uma.es/rest/oai/requestoai:riuma.uma.es:10630/340672026-02-03T11:29:46Zcom_10630_2254col_10630_37953
RIUMA. Repositorio Institucional de la Universidad de Málaga
author
Clemente-Postigo, María Mercedes
author
Muñoz Garach, Araceli
author
Serrano, Marta
author
Garrido-Sánchez, Lourdes
author
Bernal-López, María Rosa
author
Fernandez-García, Diego
author
Moreno Santos, Inmaculada
author
Garriga, Nuria
author
Castellano-Castillo, Daniel
author
Camargo, Antonio
author
Fernández Real, José M
author
Cardona-Díaz, Fernando
author
Tinahones-Madueño, Francisco José
author
Macías-González, Manuel
2024-09-30T12:31:23Z
2024-09-30T12:31:23Z
2015
Clemente-Postigo M, Muñoz-Garach A, Serrano M, Garrido-Sánchez L, Bernal-López MR, Fernández-García D, Moreno-Santos I, Garriga N, Castellano-Castillo D, Camargo A, Fernández-Real JM, Cardona F, Tinahones FJ, Macías-González M. Serum 25-hydroxyvitamin D and adipose tissue vitamin D receptor gene expression: relationship with obesity and type 2 diabetes. J Clin Endocrinol Metab. 2015 Apr;100(4):E591-5. doi: 10.1210/jc.2014-3016. Epub 2015 Feb 23. PMID: 25706239.
https://hdl.handle.net/10630/34067
10.1210/jc.2014-3016
Context: The relationship between 25-hydroxyvitamin D [25(OH)D] and obesity and type 2 diabetes is not completely understood. Vitamin D receptor (VDR) expression in adipose tissue (AT) is related to obesity and might be regulated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].
Objective: To analyze serum 25(OH)D and VDR gene expression in AT according to body mass index (BMI) and glycemic status and the effect of 1,25(OH)2D3 on AT according to BMI.
Design and patients: Two cohorts were studied: 1) 118 subjects classified according to their BMI (lean, overweight, obese, or morbidly obese [MO]) and their glycemic status (normoglycemic [NG] and prediabetic and diabetic [P&D]); and 2) 30 obese subjects (BMI > 30 kg/m(2)) classified as NG and P&D. VDR gene expression was analyzed during preadipocyte differentiation and in vitro stimulation with 1,25(OH)2D3 of AT explants from donors with different BMI values.
Setting: University Hospital.
Main outcome measures: Serum 25(OH)D, parathyroid hormone (PTH), and AT VDR gene expression.
Results: 25(OH)D levels were lower in P&D than NG subjects, significantly so in the lean and MO groups (P < .05). 25(OH)D levels correlated negatively with homeostasis model of assessment for insulin resistance (HOMA-IR) (r = -0.200; P = .032) and glucose (r = -0.295; P = .001), but not with BMI. VDR gene expression was higher in MO than in the other BMI groups (P < .05). 1,25(OH)2D3 increased VDR gene expression in AT from obese patients (P < .05) but not from lean subjects.
Conclusions: 25(OH)D levels are diminished in P&D compared to NG subjects, independently of BMI, and are closely related to glucose metabolism variables, suggesting that vitamin D deficiency is associated more with carbohydrate metabolism than with obesity. Moreover, AT has a different response to 1,25(OH)2D3 depending on the degree of obesity.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Obesidad
Diabetes
Serum 25-Hydroxyvitamin D and Adipose Tissue Vitamin D Receptor Gene Expression: Relationship with Obesity and Type 2 Diabetes
journal article
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