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Effect of apolipoprotein C3 and apolipoprotein A1 polymorphisms on postprandial response to a fat overload in metabolic syndrome patients Clemente-Postigo, María Mercedes Queipo-Ortuño, María Isabel Valdivieso-Felices, Pedro Tinahones-Madueño, Francisco José Cardona-Díaz, Fernando Apolipoproteínas Síndrome metabólico Objectives: Apolipoprotein C-III (APOC3) is a component of triglyceride rich lipoproteins, and SstI polymorphism has been associated with hypertriglyceridemia. Apolipoprotein A-I (APOA1) is the major component of HDL and MspI polymorphism has been associated with APOA1 and HDL-C levels. Thus, we study the influence of these polymorphisms in the postprandial response in metabolic syndrome (MS). Design and methods: 73 MS patients and 21 healthy subjects underwent a fat overload, with measurements of their fasting and postprandial lipid profile. The APOC3 SstI and the APOA1MspI polymorphisms were genotyped. Results: No significant differences were found in the lipid profile with respect to the MspI genotype. Patients with the S2S2 APOC3 genotype had significantly higher fasting and postprandial triglyceride levels and postprandial APOC3 and chylomicron-triglyceride levels compared with the other SstI APOC3 genotypes. Conclusions: Homozygosity for the minor allele of the APOC3 SstI polymorphism was associated to a worse postprandial response in MS patients. 2024-10-01T08:02:48Z 2024-10-01T08:02:48Z 2010 journal article M. Clemente-Postigo, M. Queipo-Ortuño, P. Valdivielso, F.J. Tinahones, F. Cardona, Effect of apolipoprotein C3 and apolipoprotein A1 polymorphisms on postprandial response to a fat overload in metabolic syndrome patients, Clinical Biochemistry, Volume 43, Issues 16–17, 2010, Pages 1300-1304, ISSN 0009-9120, https://doi.org/10.1016/j.clinbiochem.2010.08.014. https://hdl.handle.net/10630/34108 10.1016/j.clinbiochem.2010.08.014 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier. The Canadian Society of Clinical Chemists.